Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 3/20 | 0.47 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | PYGL | P06737 | 1/20 | 0.36 |
| ▸ | PYGM | P11217 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | GUSB | P08236 | 1/20 | 0.35 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.35 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16571158 | 0.89 | ALOX15 (0.49) | ALOX15KMT2ACNR2MEN1GUSB | |
| SCHEMBL16570654 | 0.89 | RIPK1 (0.41) | ALOX15KMT2AMEN1RXFP1 | |
| SCHEMBL16571203 | 0.86 | GRM2 (0.41) | TRPA1PTGESHRH4GUSB | |
| SCHEMBL16571420 | 0.85 | ALOX15 (0.49) | ALOX15KMT2ACNR2NUDT1 | |
| SCHEMBL16571121 | 0.84 | XDH (0.39) | ALOX15NUDT1 | |
| SCHEMBL16571406 | 0.83 | PDE4A (0.41) | ALOX15NUDT1 | |
| SCHEMBL16570969 | 0.82 | LRRK2 (0.40) | ALOX15KMT2AMEN1RXFP1NUDT1 | |
| SCHEMBL16571417 | 0.81 | XDH (0.38) | ALOX15KMT2AMEN1RXFP1 | |
| SCHEMBL16570967 | 0.81 | ALOX15 (0.35) | ALOX15HRH4KMT2AMEN1RXFP1 | |
| SCHEMBL19478398 | 0.78 | XDH (0.39) | ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3044207-A1 | INDOL-CARBOXAMIDE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2016-07-20 | — | — | EP | disclosed |
| WO-2015036412-A1 | INDOL-CARBOXAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2015-03-19 | — | — | WO | disclosed |