SCHEMBL3086322

SCHEMBL3086322

Cc1cccc(C(=O)NC(C)C)c1NC(=O)c1cc(Br)nn1-c1ncccc1Cl

nearest known ligand 0.67

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 3/20 0.49
MAPK14 Q16539 1/20 0.38
PDE4A P27815 2/20 0.37
KCNH2 Q12809 1/20 0.36
CAPN1 P07384 1/20 0.35
PYGL P06737 2/20 0.35
CHRNA7 P36544 4/20 0.35
MALT1 Q9UDY8 1/20 0.35
LCK P06239 2/20 0.34
MAPT P10636 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3094463 0.91 DHODH (0.41) DHODHMAPK14PDE4AKCNH2CAPN1
SCHEMBL782222 0.90 DHODH (0.43) DHODHPDE4AKCNH2CAPN1MALT1
SCHEMBL14361041 0.90 DHODH (0.43) DHODHPDE4AKCNH2CAPN1MALT1
SCHEMBL782232 0.90 DHODH (0.43) DHODHPDE4AKCNH2CAPN1MALT1
SCHEMBL10028768 0.89 DHODH (0.43) DHODHPDE4AKCNH2CAPN1MALT1
SCHEMBL12438370 0.89 DHODH (0.42) DHODHPDE4AKCNH2CAPN1CHRNA7
SCHEMBL842004 0.88 DHODH (0.51) DHODHCHRNA7MALT1LCKMAPT
SCHEMBL13318558 0.88 DHODH (0.48) DHODHCHRNA7MALT1LCKMAPT
SCHEMBL3200941 0.88 DHODH (0.49) DHODHMAPK14CHRNA7MALT1LCK
SCHEMBL12911683 0.88 DHODH (0.49) DHODHCHRNA7MALT1LCKMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2910125-B1 INSECTICIDE COMPOSITIONS SUMITOMO CHEMICAL CO (JP) 2018-05-02 EP claimed
US-20160270396-A1 INSECTICIDE COMPOSITIONS SUMITOMO CHEMICAL CO (JP) 2016-09-22 US claimed
US-9408390-B2 Insecticide compositions SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2016-08-09 US claimed
US-20150282484-A1 INSECTICIDE COMPOSITIONS SUMITOMO CHEMICAL CO (JP) 2015-10-08 US claimed
EP-2910125-A1 Insecticide compositions Sumitomo Chemical Company, Limited (JP) 2015-08-26 EP claimed
EP-2474227-B1 Insecticide compositions SUMITOMO CHEMICAL CO (JP) 2015-04-15 EP claimed
EP-2484209-B1 Insecticide compositions SUMITOMO CHEMICAL CO (JP) 2015-04-01 EP claimed
EP-2484209-A1 Insecticide compositions Sumitomo Chemical Company, Limited (JP) 2012-08-08 EP claimed
EP-1719409-B1 INSECTICIDE COMPOSITION SUMITOMO CHEMICAL CO (JP) 2012-07-11 EP claimed
EP-2474227-A1 Insecticide compositions Sumitomo Chemical Co., Ltd (JP) 2012-07-11 EP claimed
US-20100227893-A1 INSECTICIDE COMPOSITIONS OHKAWARA YUICHI 2010-09-09 US claimed
US-20070259787-A1 Insecticide Compositions SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2007-11-08 US claimed
EP-1719409-A1 INSECTICIDE COMPOSITION Sumitomo Chemical Takeda Agro Company, Limited (JP) 2006-11-08 EP claimed
EP-2910125-B1 INSECTICIDE COMPOSITIONS SUMITOMO CHEMICAL CO (JP) 2018-05-02 EP disclosed
US-20160270396-A1 INSECTICIDE COMPOSITIONS SUMITOMO CHEMICAL CO (JP) 2016-09-22 US disclosed
US-9408390-B2 Insecticide compositions SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2016-08-09 US disclosed
EP-2474227-A1 Insecticide compositions Sumitomo Chemical Co., Ltd (JP) 2012-07-11 EP disclosed
US-20100227893-A1 INSECTICIDE COMPOSITIONS OHKAWARA YUICHI 2010-09-09 US disclosed
US-20070259787-A1 Insecticide Compositions SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2007-11-08 US disclosed
EP-1719409-A1 INSECTICIDE COMPOSITION Sumitomo Chemical Takeda Agro Company, Limited (JP) 2006-11-08 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100227893-A1 INSECTICIDE COMPOSITIONS DDT, NISCH, ITPR3 DHODH 830/4885MAPK14 2538/4885PDE4A 387/4885
US-20070259787-A1 Insecticide Compositions DDT, NISCH, ITPR3 DHODH 830/4885MAPK14 2538/4885PDE4A 387/4885
US-20160270396-A1 INSECTICIDE COMPOSITIONS DDT, NISCH, ITPR3 DHODH 830/4885MAPK14 2538/4885PDE4A 387/4885
US-20150282484-A1 INSECTICIDE COMPOSITIONS DDT, NISCH, ITPR3 DHODH 830/4885MAPK14 2538/4885PDE4A 387/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.