Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.46 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.46 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2254970 | 0.98 | KMT2A (0.50) | KMT2AMEN1MAPK1CYP1A2SMN1; SMN2 | |
| SCHEMBL16829928 | 0.88 | SMN1; SMN2 (0.57) | KMT2AMEN1MAPK1CYP1A2SMN1; SMN2 | |
| SCHEMBL165769 | 0.84 | KMT2A (0.54) | KMT2AMEN1MAPK1CYP1A2SMN1; SMN2 | |
| SCHEMBL167209 | 0.82 | KMT2A (0.51) | KMT2AMEN1MAPK1CYP1A2SMN1; SMN2 | |
| SCHEMBL10386591 | 0.81 | KMT2A (0.51) | KMT2AMEN1MAPK1CYP1A2ALDH1A1 | |
| SCHEMBL17387575 | 0.81 | ALDH1A1 (0.54) | KMT2AMEN1ALDH1A1POLBKDM4E | |
| SCHEMBL5093580 | 0.81 | L3MBTL1 (0.55) | KMT2AMEN1MAPK1CYP1A2SMN1; SMN2 | |
| SCHEMBL5111511 | 0.81 | KMT2A (0.51) | KMT2AMEN1MAPK1CYP1A2SMN1; SMN2 | |
| SCHEMBL14959640 | 0.81 | KMT2A (0.51) | KMT2AMEN1MAPK1CYP1A2SMN1; SMN2 | |
| SCHEMBL328570 | 0.81 | KMT2A (0.51) | KMT2AMEN1MAPK1CYP1A2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9018197-B2 | Tetradecahydro-1H-cyclopenta[a]phenanthrene compounds, compositions, and related methods of use | SUZHOU NEUPHARMA CO. LTD. (CN) | 2015-04-28 | — | — | US | claimed |
| CN-102656179-A | Bufalin derivatives, pharmaceutical compositions and uses thereof | SUZHOU NEUPHARMA CO LTD | 2012-09-05 | — | — | CN | claimed |
| CN-102656179-B | Bufalin derivatives, pharmaceutical compositions and uses thereof | SUZHOU NEUPHARMA Co.,Ltd. (CN) | 2015-07-29 | — | — | CN | disclosed |
| US-9018197-B2 | Tetradecahydro-1H-cyclopenta[a]phenanthrene compounds, compositions, and related methods of use | SUZHOU NEUPHARMA CO. LTD. (CN) | 2015-04-28 | — | — | US | disclosed |
| CN-102656179-A | Bufalin derivatives, pharmaceutical compositions and uses thereof | SUZHOU NEUPHARMA CO LTD | 2012-09-05 | — | — | CN | disclosed |
| WO-2012027957-A1 | BUFALIN DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND USE THEREOF | SUZHOU NEUPHARMA CO., LTD. (CN) | 2012-03-08 | — | — | WO | disclosed |