Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.50 |
| ▸ | MAOB | P27338 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | PNMT | P11086 | 1/20 | 0.50 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | DRD1 | P21728 | 2/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | DRD5 | P21918 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20232216 | 1.00 | MAOA (0.50) | MAOAMAOBMEN1KMT2AADRA2A | |
| SCHEMBL29558059 | 0.95 | ADRA2A (0.51) | MAOAMAOBMEN1KMT2AADRA2A | |
| SCHEMBL324724 | 0.95 | ADRA2A (0.51) | MAOAMAOBMEN1KMT2AADRA2A | |
| SCHEMBL1950525 | 0.95 | PNMT (0.54) | MEN1KMT2AADRA2APNMTSIRT6 | |
| Hydrochloric Acid SCHEMBL7832321 | 0.94 | ADRA2A (0.50) | MAOAMAOBMEN1KMT2AADRA2A | |
| SCHEMBL29119402 | 0.89 | LMNA (0.50) | ADRA2APNMTSIRT6POLBNPC1 | |
| SCHEMBL29945643 | 0.86 | DPP7 (0.50) | MEN1KMT2AADRA2APNMTSIRT6 | |
| SCHEMBL1952321 | 0.86 | LMNA (0.50) | MEN1KMT2AADRA2APNMTSIRT6 | |
| SCHEMBL30612412 | 0.82 | ACHE (0.44) | MEN1KMT2AADRA2APNMTSIRT6 | |
| SCHEMBL13012409 | 0.81 | HTR1A (0.47) | MEN1KMT2AADRA2APNMTSIRT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4320121-A2 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES AS ULK1/2 INHIBITORS AND THEIR USE THEREOF | LifeArc (GB) | 2024-02-14 | — | — | EP | disclosed |
| CN-117545751-A | 2, 4-diaminopyrimidine derivatives as ULK1/2 inhibitors and their use | 生命爱科 | 2024-02-09 | — | — | CN | disclosed |
| WO-2022214869-A2 | ULK1/2 INHIBITORS AND THEIR USE THEREOF | LIFEARC (GB) | 2022-10-13 | — | — | WO | disclosed |