SCHEMBL1658650

SCHEMBL1658650

CC1=Nc2ncc(Br)cc2C1(C)C

nearest known ligand 0.33

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.33
HTT P42858 2/20 0.32
ALDH1A1 P00352 1/20 0.32
MAPT P10636 1/20 0.32
MAPK1 P28482 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
KMT2A Q03164 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10265050 0.78 HRH4 (0.31)
SCHEMBL4619322 0.73 PSMB5 (0.40) SMN1; SMN2ALDH1A1MAPTNPSR1KMT2A
SCHEMBL71083 0.70 SMN1; SMN2 (0.37) SMN1; SMN2HTTALDH1A1MAPTMAPK1
SCHEMBL29154631 0.68 PDGFRB (0.43) SMN1; SMN2ALDH1A1MAPTKMT2A
SCHEMBL317019 0.68 MEN1 (0.39) ALDH1A1MAPK1NPSR1KMT2A
SCHEMBL18937217 0.66 CCND3 (0.34)
SCHEMBL1655723 0.65 KMT2A (0.34) ALDH1A1MAPTKMT2A
SCHEMBL2184823 0.64 MEN1 (0.35) ALDH1A1MAPK1NPSR1KMT2A
SCHEMBL8919222 0.62 MAP3K11 (0.51) SMN1; SMN2
SCHEMBL1658653 0.61 AKR1B1 (0.35) SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 104 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250084250-A1 AZAINDOLE CYANINE DYES, USES, AND METHODS OF PREPARATION LIFE TECHNOLOGIES CORP (US) 2025-03-13 US disclosed
US-20240182451-A1 AZAINDOLE CYANINE DYES, USES, AND METHODS OF PREPARATION Life Technologies Corporation 2024-06-06 US disclosed
EP-4373891-A2 AZAINDOLE CYANINE DYES, USES, AND METHODS OF PREPARATION Life Technologies Corporation (US) 2024-05-29 EP disclosed
CN-117529529-A Azaindole cyanine dye, application and preparation method 生命技术公司 2024-02-06 CN disclosed
US-20230219932-A1 COMPOUND AND LABELED BIOLOGICAL SUBSTANCE USING THE SAME FUJIFILM CORPORATION (JP) 2023-07-13 US disclosed
WO-2023004356-A2 AZAINDOLE CYANINE DYES, USES, AND METHODS OF PREPARATION Life Technologies Corporation (US) 2023-01-26 WO disclosed
WO-2023004356-A2 AZAINDOLE CYANINE DYES, USES, AND METHODS OF PREPARATION Life Technologies Corporation (US) 2023-01-26 WO disclosed
WO-2021215514-A1 COMPOUND AND LABELED BIOMATERIAL IN WHICH SAME IS USED 富士フイルム株式会社 (JP) 2021-10-28 WO disclosed
EP-2630196-B1 CYANINE DYES AND THEIR CONJUGATES LI COR INC (US) 2017-09-06 EP disclosed
EP-2630196-B1 CYANINE DYES AND THEIR CONJUGATES LI COR INC (US) 2017-09-06 EP disclosed
US-20060099638-A1 Modified carbocyanine dyes and their conjugates MOLECULAR PROBES, INC. 2006-05-11 US disclosed
US-20060004188-A1 Intermediates and the synthesis of modified carbocyanine dyes and their conjugates MOLECULAR PROBES, INC. 2006-01-05 US disclosed
US-6977305-B2 Modified carbocyanine dyes and their conjugates MOLECULAR PROBES, INC. (US) 2005-12-20 US disclosed
US-6974873-B2 Modified carbocyanine dyes and their conjugates MOLECULAR PROBES, INC. (US) 2005-12-13 US disclosed
US-20050112770-A1 Method for optical measurement of multi-stranded nucleic acid FUJI PHOTO FILM CO., LTD. 2005-05-26 US disclosed
EP-1362894-A2 Method for optical measurement of multi-stranded nucleic acid using cyanine dyes FUJI PHOTO FILM CO., LTD. (JP) 2003-11-19 EP disclosed
EP-1322710-A1 MODIFIED CARBOCYANINE DYES AND THEIR CONJUGATES Molecular Probes Inc. (US) 2003-07-02 EP disclosed
US-20020077487-A1 Modified carbocyanine dyes and their conjugates MOLECULAR PROBES, INC. 2002-06-20 US disclosed
US-20020064794-A1 Modified carbocyanine dyes and their conjugates MOLECULAR PROBES, INC. 2002-05-30 US disclosed
WO-2002026891-A1 MODIFIED CARBOCYANINE DYES AND THEIR CONJUGATES MOLECULAR PROBES, INC. (US) 2002-04-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020077487-A1 Modified carbocyanine dyes and their conjugates IK, CBR3, DRD5 SMN1; SMN2 4216/4885HTT 1394/4885ALDH1A1 385/4885
US-20230219932-A1 COMPOUND AND LABELED BIOLOGICAL SUBSTANCE USING THE SAME BMP1, BMP2, NPSR1 SMN1; SMN2 2526/4885HTT 4848/4885ALDH1A1 644/4885
US-20240182451-A1 AZAINDOLE CYANINE DYES, USES, AND METHODS OF PREPARATION AZI2, IK, HCCS SMN1; SMN2 3998/4885HTT 3281/4885ALDH1A1 2795/4885
US-20060004188-A1 Intermediates and the synthesis of modified carbocyanine dyes and their conjugates CBR3, IK, CYBA SMN1; SMN2 4319/4885HTT 1194/4885ALDH1A1 181/4885
US-20060099638-A1 Modified carbocyanine dyes and their conjugates IK, CBR3, DRD5 SMN1; SMN2 4216/4885HTT 1394/4885ALDH1A1 385/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.