Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.31 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13538484 | 0.88 | ALOX5 (0.37) | ALOX5ROCK1CYP2C19PYCR1TRPM8 | |
| SCHEMBL13010741 | 0.79 | CACNA1G (0.35) | ALOX5ROCK1CACNA1G | |
| SCHEMBL3655071 | 0.79 | KMT2A (0.39) | ALOX5SLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL13077090 | 0.79 | SLC6A4 (0.42) | ALOX5SLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL15959054 | 0.79 | EPHX2 (0.34) | ROCK1ALDH1A1TRPM8 | |
| SCHEMBL3655073 | 0.79 | KMT2A (0.39) | ALOX5SLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL18380908 | 0.79 | ALOX5 (0.35) | ALOX5ROCK1SLC6A2SLC6A3ALDH1A1 | |
| SCHEMBL15436313 | 0.78 | CYP2C19 (0.40) | ALOX5CYP2C19SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL13538362 | 0.78 | CYP2C19 (0.40) | ALOX5CYP2C19SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL13552270 | 0.78 | TRPM8 (0.34) | ROCK1CYP2C19ALDH1A1NPSR1TRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2220052-B1 | CYCLIC UREA INHIBITORS OF 11ß-HYDROXYSTEROID DEHYDROGENASE 1 | VITAE PHARMACEUTICALS INC (US) | 2015-03-25 | — | — | EP | disclosed |