Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 1/20 | 0.43 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.37 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.37 |
| ▸ | BMP1 | P13497 | 1/20 | 0.36 |
| ▸ | NMT2 | O60551 | 2/20 | 0.36 |
| ▸ | NMT1 | P30419 | 2/20 | 0.36 |
| ▸ | CCKBR | P32239 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
| ▸ | TACR3 | P29371 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16589748 | 0.88 | CCKBR (0.45) | GRIA1SIRT6SIRT1CCKBR | |
| SCHEMBL16589722 | 0.85 | GRIA1 (0.44) | GRIA1SIRT6SIRT1TACR1TACR3 | |
| SCHEMBL16589733 | 0.85 | GRIA1 (0.36) | GRIA1DPP4DPP8DPP9BMP1 | |
| SCHEMBL16589724 | 0.84 | SIRT6 (0.55) | GRIA1SIRT6SIRT1NMT2NMT1 | |
| SCHEMBL16589738 | 0.81 | GRIA1 (0.46) | GRIA1SIRT6SIRT1NMT2NMT1 | |
| SCHEMBL16589742 | 0.81 | CTSS (0.46) | GRIA1SIRT6SIRT1 | |
| SCHEMBL16589746 | 0.81 | GRIA1 (0.45) | GRIA1SIRT6SIRT1NMT2NMT1 | |
| SCHEMBL16589725 | 0.80 | GRIA1 (0.45) | GRIA1SIRT6SIRT1SMN1; SMN2TACR1 | |
| SCHEMBL15359494 | 0.79 | NMT1 (0.41) | SIRT6SIRT1DPP4DPP8DPP9 | |
| SCHEMBL16589749 | 0.79 | GRIA1 (0.44) | GRIA1SIRT6SIRT1CCKBRTACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150087688-A1 | PRODRUGS OF HYDROXYL-COMPRISING DRUGS | ASCENDIS PHARMA GMBH (DE) | 2015-03-26 | — | — | US | disclosed |
| US-20150087688-A1 | PRODRUGS OF HYDROXYL-COMPRISING DRUGS | ASCENDIS PHARMA GMBH (DE) | 2015-03-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150087688-A1 | PRODRUGS OF HYDROXYL-COMPRISING DRUGS | ABCB1, CYP2D6, LDHA | GRIA1 3272/4885SIRT6 1290/4885SIRT1 789/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.