Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | ACACB | O00763 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26696658 | 0.90 | ALDH1A1 (0.40) | ALDH1A1ACACBPKMTHRBMEN1 | |
| SCHEMBL10035850 | 0.87 | PKM (0.36) | ALDH1A1ACACBPKMTHRBMEN1 | |
| SCHEMBL22508202 | 0.84 | ALDH1A1 (0.41) | ALDH1A1LMNAHSD17B10 | |
| SCHEMBL25511794 | 0.84 | ALDH1A1 (0.49) | ALDH1A1LMNAHSD17B10 | |
| SCHEMBL22296807 | 0.82 | THRB (0.31) | ALDH1A1ACACBPKMTHRBHTT | |
| SCHEMBL22104690 | 0.82 | THRB (0.32) | ALDH1A1ACACBPKMTHRBHTT | |
| SCHEMBL24821941 | 0.81 | — | — | |
| SCHEMBL21541121 | 0.81 | ALDH1A1 (0.39) | ALDH1A1MEN1KMT2A | |
| SCHEMBL13460305 | 0.81 | ALDH1A1 (0.32) | ALDH1A1 | |
| SCHEMBL21415343 | 0.81 | PKM (0.31) | PKMHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015042447-A1 | TARGETED THERAPEUTIC NUCLEOSIDES AND THEIR USE | ISIS PHARMACEUTICALS, INC. (US) | 2015-03-26 | — | — | WO | disclosed |