Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 1/20 | 0.52 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.52 |
| ▸ | PSEN1 | P49768 | 6/20 | 0.49 |
| ▸ | PSEN2 | P49810 | 6/20 | 0.49 |
| ▸ | APH1B | Q8WW43 | 6/20 | 0.49 |
| ▸ | NCSTN | Q92542 | 6/20 | 0.49 |
| ▸ | APH1A | Q96BI3 | 6/20 | 0.49 |
| ▸ | PSENEN | Q9NZ42 | 6/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.48 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16252564 | 0.84 | SMARCA2 (0.58) | SMARCA2SMARCA4PSEN1PSEN2APH1B | |
| SCHEMBL18626324 | 0.84 | SMARCA2 (0.55) | SMARCA2SMARCA4HSD17B10CA1CA2 | |
| SCHEMBL16596226 | 0.84 | HSD17B10 (0.48) | HSD17B10CA1CA2CA7CA14 | |
| SCHEMBL16596227 | 0.81 | HSD17B10 (0.52) | HSD17B10CA1CA2CA7CA14 | |
| SCHEMBL16596228 | 0.80 | SMARCA2 (0.54) | SMARCA2SMARCA4CA1CA2CA7 | |
| SCHEMBL13134416 | 0.79 | LMNA (0.60) | HSD17B10CA1CA2CA7CA14 | |
| SCHEMBL18899922 | 0.78 | SMARCA2 (0.58) | SMARCA2SMARCA4SORT1LMNATSHR | |
| SCHEMBL19116340 | 0.77 | PTPN1 (0.54) | SMARCA2SMARCA4SORT1LMNATSHR | |
| SCHEMBL15880685 | 0.77 | SMARCA2 (0.65) | SMARCA2SMARCA4PSEN1PSEN2APH1B | |
| SCHEMBL1949535 | 0.76 | HSD17B10 (0.69) | HSD17B10CA1CA2CA7CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015042363-A1 | MOLECULES AND COMPOSITIONS THAT INHIBIT GRAM NEGATIVE BACTERIA AND THEIR USES | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2015-03-26 | — | — | WO | disclosed |