SCHEMBL16596453

SCHEMBL16596453

B=Cc1cc(-c2cccs2)ccc1C(F)(F)F

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ERN1 O75460 4/20 0.55
KCNH2 Q12809 1/20 0.44
CCNE2 O96020 2/20 0.40
CCNE1 P24864 2/20 0.40
CDK2 P24941 2/20 0.40
CDK4 P11802 1/20 0.40
CCND1 P24385 1/20 0.40
PDK2 Q15119 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.38
LTA4H P09960 1/20 0.38
ACHE P22303 1/20 0.37
TNFRSF1A P19438 2/20 0.36
KDM4E B2RXH2 2/20 0.36
PGR P06401 1/20 0.36
MAPT P10636 1/20 0.36
SLC6A11 P48066 1/20 0.36
RXFP1 Q9HBX9 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
ALDH1A1 P00352 1/20 0.36
GAA P10253 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28222643 0.76 ERN1 (0.51) ERN1KCNH2CCNE2CCNE1CDK2
SCHEMBL20169308 0.76 ERN1 (0.48) ERN1KCNH2CCNE2CCNE1CDK2
SCHEMBL16596476 0.76 ERN1 (0.48) ERN1KCNH2CCNE2CCNE1CDK2
SCHEMBL2368386 0.72 ERN1 (0.51) ERN1KCNH2PDK2LTA4H
SCHEMBL20169301 0.72 ERN1 (0.51) ERN1KCNH2CCNE2CCNE1CDK2
SCHEMBL12767025 0.71 ERN1 (1.00) ERN1
SCHEMBL13639950 0.71 ERN1 (0.71) ERN1KCNH2CCNE2CCNE1CDK2
SCHEMBL154628 0.70 LTA4H (0.53) ERN1KCNH2PDK2SMN1; SMN2LTA4H
SCHEMBL8002483 0.69 KIF11 (0.56) ERN1KCNH2PDK2LTA4H
SCHEMBL15203026 0.68 KCNH2 (0.50) ERN1KCNH2CCNE2CCNE1CDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015041026-A1 BENZOBIS (THIADIAZOLE) DERIVATIVE, INK CONTAINING SAME, AND ORGANIC ELECTRONIC DEVICE USING SAME 宇部興産株式会社 2015-03-26 WO disclosed