Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 3/20 | 0.47 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.47 |
| ▸ | JAK3 | P52333 | 3/20 | 0.46 |
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.46 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25069375 | 0.91 | GABRA1 (0.53) | GABRA1GABRB2GABRB1GABRA3MEN1 | |
| SCHEMBL23731297 | 0.80 | GABRA1 (0.51) | GABRA1GABRB2JAK3JAK2GABRB1 | |
| SCHEMBL25069322 | 0.78 | GABRA1 (0.54) | GABRA1GABRB2GABRB1GABRA3MEN1 | |
| SCHEMBL29027116 | 0.78 | GABRA1 (0.51) | GABRA1GABRB2JAK3JAK2GABRB1 | |
| SCHEMBL29550066 | 0.78 | GABRA1 (0.51) | GABRA1GABRB2JAK3JAK2GABRB1 | |
| SCHEMBL22864631 | 0.77 | NR4A2 (0.54) | GABRA1GABRB2GABRB1GABRA3TSHR | |
| SCHEMBL29800593 | 0.77 | NR4A2 (0.54) | GABRA1GABRB2GABRB1GABRA3TSHR | |
| SCHEMBL13325448 | 0.76 | CES2 (0.38) | ALDH1A1HSD17B10CYP3A4 | |
| SCHEMBL8911574 | 0.75 | CYP1A2 (0.49) | GABRA1GABRB2JAK3JAK2GABRB1 | |
| SCHEMBL23147875 | 0.74 | HPGD (0.49) | TSHRMEN1ALDH1A1TP53HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105593211-B | Indole and indazole derivatives | 豪夫迈·罗氏有限公司 | 2021-07-27 | — | — | CN | disclosed |
| EP-3049391-B1 | INDOLE AND INDAZOLE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2018-12-26 | — | — | EP | disclosed |
| US-9708259-B2 | Indol and indazol derivatives | HOFFMANN-LA ROCHE INC. (US) | 2017-07-18 | — | — | US | disclosed |
| EP-3049391-A1 | INDOL AND INDAZOL DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2016-08-03 | — | — | EP | disclosed |
| US-20160207885-A1 | INDOL AND INDAZOL DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2016-07-21 | — | — | US | disclosed |
| WO-2015044072-A1 | INDOL AND INDAZOL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2015-04-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160207885-A1 | INDOL AND INDAZOL DERIVATIVES | CHRNA7, CHRM1, CHRNA3 | GABRA1 815/4885GABRB2 1127/4885JAK3 1514/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.