Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | GLS | O94925 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGDS | O60760 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16598021 | 0.81 | SMN1; SMN2 (0.55) | SMN1; SMN2KMT2AALDH1A1HPGDSKDM4E | |
| SCHEMBL8722201 | 0.79 | SMN1; SMN2 (0.69) | HTTGLSSMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL1569186 | 0.78 | HPGDS (0.54) | SMN1; SMN2KMT2AALDH1A1HPGDSKDM4E | |
| SCHEMBL21016887 | 0.76 | GLS (0.58) | HTTGLSTSHRSMN1; SMN2KMT2A | |
| SCHEMBL12332384 | 0.75 | NPSR1 (0.49) | TSHRSMN1; SMN2KMT2AHPGDS | |
| SCHEMBL2937818 | 0.75 | HPGDS (0.46) | TSHRSMN1; SMN2HPGDS | |
| SCHEMBL31098478 | 0.75 | HTT (0.63) | HTTTSHRSMN1; SMN2KMT2AHDAC3 | |
| SCHEMBL7975613 | 0.75 | TSHR (0.68) | HTTTSHRSMN1; SMN2KMT2AHDAC3 | |
| SCHEMBL16598445 | 0.73 | HTT (0.66) | HTTTSHRSMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL3083971 | 0.73 | HTT (0.75) | HTTTSHRSMN1; SMN2KMT2AHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015048503-A2 | N-ARYLMETHYL SULFONAMIDE NEGATIVE MODULATORS OF NR2A | MNEMOSYNE PHARMACEUTICALS, INC. (US) | 2015-04-02 | — | — | WO | disclosed |