Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 4/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | IDO1 | P14902 | 3/20 | 0.47 |
| ▸ | IDO2 | Q6ZQW0 | 3/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8722201 | 0.77 | SMN1; SMN2 (0.69) | GLSHTTSMN1; SMN2KMT2ALMNA | |
| SCHEMBL26326042 | 0.77 | MIF (0.62) | HTTTSHRSMN1; SMN2LMNAKDM4E | |
| SCHEMBL16598138 | 0.76 | HTT (0.51) | GLSHTTTSHRSMN1; SMN2KMT2A | |
| SCHEMBL12339931 | 0.76 | TUBB4A (0.67) | HDAC1 | |
| SCHEMBL19662980 | 0.76 | NOTUM (0.50) | ALOX15 | |
| SCHEMBL17369045 | 0.75 | GLS (0.45) | GLSLMNAKDM4ERAB9A | |
| SCHEMBL19448065 | 0.74 | GLS (0.89) | GLS | |
| SCHEMBL2516053 | 0.74 | KDM4E (0.69) | HTTTSHRSMN1; SMN2KMT2AHDAC3 | |
| SCHEMBL17411587 | 0.73 | GLS (1.00) | GLS | |
| SCHEMBL31098478 | 0.73 | HTT (0.63) | HTTTSHRSMN1; SMN2KMT2AHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10994006-B2 | Desensitizing mast cells by co-presentation of antigens with high affinity mast cell siglec ligands | THE SCRIPPS RESEARCH INSTITUTE (US) | 2021-05-04 | — | — | US | disclosed |
| US-20190151444-A1 | DESENSITIZING MAST CELLS BY CO-PRESENTATION OF ANTIGENS WITH HIGH AFFINITY MAST CELL SIGLEC LIGANDS | THE SCRIPPS RESEARCH INSTITUTE | 2019-05-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190151444-A1 | DESENSITIZING MAST CELLS BY CO-PRESENTATION OF ANTIGENS WITH HIGH AFFINITY MAST CELL SIGLEC LIGANDS | FCGR1A, CPA3, FCER2 | GLS 4759/4885HTT 4691/4885TSHR 2994/4885 |
| US-10994006-B2 | Desensitizing mast cells by co-presentation of antigens with high affinity mast cell siglec ligands | FCGR1A, CPA3, FCER2 | GLS 4759/4885HTT 4691/4885TSHR 2994/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.