Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.78 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.78 |
| ▸ | FABP1 | P07148 | 1/20 | 0.66 |
| ▸ | FABP6 | P51161 | 1/20 | 0.66 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.66 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | FAAH | O00519 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17954124 | 0.84 | GRIN2B (0.62) | ALDH1A1HSD17B10GRIN2BSMN1; SMN2FAAH | |
| Befuraline SCHEMBL30036410 | 0.84 | GRIN2B (0.91) | ALDH1A1GRIN2BLMNATSHRSMN1; SMN2 | |
| Befuraline SCHEMBL499156 | 0.84 | GRIN2B (0.91) | ALDH1A1GRIN2BLMNATSHRSMN1; SMN2 | |
| SCHEMBL4991177 | 0.83 | GRIN2B (0.77) | ALDH1A1GRIN2BSMN1; SMN2MAPT | |
| Befuraline SCHEMBL4320804 | 0.83 | GRIN2B (0.88) | ALDH1A1GRIN2BLMNATSHRSMN1; SMN2 | |
| SCHEMBL4750999 | 0.82 | HTR2B (0.67) | ALDH1A1HSD17B10KDM4E | |
| SCHEMBL13546093 | 0.80 | FABP1 (1.00) | ALDH1A1FABP1FABP6NR1H4LMNA | |
| SCHEMBL16599328 | 0.79 | LMNA (0.64) | ALDH1A1HSD17B10FABP1FABP6GRIN2B | |
| SCHEMBL6501271 | 0.79 | GRIN2B (0.70) | ALDH1A1GRIN2BSMN1; SMN2MAPT | |
| SCHEMBL27663681 | 0.78 | ALDH1A1 (0.70) | ALDH1A1FABP1FABP6LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9776979-B2 | EBI2 modulators | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2017-10-03 | — | — | US | disclosed |
| US-9776979-B2 | EBI2 modulators | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2017-10-03 | — | — | US | disclosed |
| US-20160214951-A1 | EBI2 MODULATORS | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE | 2016-07-28 | — | — | US | disclosed |
| US-20160214951-A1 | EBI2 MODULATORS | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE | 2016-07-28 | — | — | US | disclosed |
| WO-2015048570-A2 | EBI2 MODULATORS | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2015-04-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160214951-A1 | EBI2 MODULATORS | BIRC2, HAVCR2, MAVS | ALDH1A1 4277/4885HSD17B10 3712/4885FABP1 1187/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.