Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 2/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.67 |
| ▸ | MEN1 | O00255 | 3/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.67 |
| ▸ | GLA | P06280 | 1/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | DRD2 | P14416 | 1/20 | 0.54 |
| ▸ | DRD3 | P35462 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Befuraline SCHEMBL499156 | 0.87 | GRIN2B (0.91) | GRIN2BALDH1A1MEN1KMT2AGLA | |
| Befuraline SCHEMBL30036410 | 0.87 | GRIN2B (0.91) | GRIN2BALDH1A1MEN1KMT2AGLA | |
| SCHEMBL4991177 | 0.86 | GRIN2B (0.77) | GRIN2BALDH1A1MEN1KMT2AGLA | |
| Befuraline SCHEMBL4320804 | 0.85 | GRIN2B (0.88) | GRIN2BALDH1A1MEN1KMT2AGLA | |
| SCHEMBL29078102 | 0.79 | GRIN2B (0.69) | GRIN2BALDH1A1MEN1KMT2AGLA | |
| SCHEMBL16599028 | 0.79 | ALDH1A1 (0.78) | GRIN2BALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL30518143 | 0.79 | GRIN2B (0.69) | GRIN2BALDH1A1MEN1KMT2AGLA | |
| SCHEMBL16598855 | 0.77 | GRIN2B (0.71) | GRIN2BALDH1A1MEN1KMT2AGLA | |
| SCHEMBL967229 | 0.76 | ALDH1A1 (0.74) | GRIN2BALDH1A1MEN1KMT2AGLA | |
| SCHEMBL19864572 | 0.76 | ALDH1A1 (1.00) | GRIN2BALDH1A1MEN1KMT2AGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050192288-A1 | Benzofuran-2-yl-carbonyl- and indol-2-yl-carbonyl-trans-2,5-dimethyl-piperazine derivatives; rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, inflammatory bowel disease, asthma; inhibit the interaction between inflammatory chemokines and their receptor | ACTIVE BIOTECH AB (SE) | 2005-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050192288-A1 | Benzofuran-2-yl-carbonyl- and indol-2-yl-carbonyl-trans-2,5-dimethyl-piperazine derivatives; rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, inflammatory bowel disease, asthma; inhibit the interaction between inflammatory chemokines and their receptor | CXCR1, CCR2, CXCR5 | GRIN2B 2582/4885ALDH1A1 2999/4885MEN1 2106/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.