Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.59 |
| ▸ | MAOB | P27338 | 4/20 | 0.50 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.50 |
| ▸ | IKBKB | O14920 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | PRNP | P04156 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | OGG1 | O15527 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL346530 | 0.86 | MCL1 (0.62) | PTGS2MAOBLIMK1HDAC1HDAC8 | |
| SCHEMBL347996 | 0.85 | LIMK1 (0.66) | PTGS2MAOBLIMK1HDAC1HDAC8 | |
| SCHEMBL30980091 | 0.85 | PTGS2 (0.56) | PTGS2MAOBLIMK1HDAC1HDAC8 | |
| SCHEMBL2503631 | 0.85 | PTGS2 (0.56) | PTGS2MAOBLIMK1HDAC1HDAC8 | |
| SCHEMBL1805430 | 0.80 | LMNA (0.69) | PTGS2MAOBLIMK1HDAC1HDAC8 | |
| SCHEMBL3978950 | 0.77 | PTGS2 (0.43) | PTGS2MAOBLIMK1HDAC1HDAC8 | |
| SCHEMBL7088656 | 0.76 | MCL1 (0.76) | HDAC1HDAC8HDAC6MCL1PRNP | |
| SCHEMBL16598796 | 0.76 | RXFP1 (0.73) | MAOBLIMK1HDAC1HDAC8HDAC6 | |
| SCHEMBL16599116 | 0.76 | LIMK1 (0.50) | PTGS2MAOBLIMK1HDAC1HDAC8 | |
| SCHEMBL6598312 | 0.76 | MAOB (0.46) | PTGS2MAOBLIMK1HDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9776979-B2 | EBI2 modulators | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2017-10-03 | — | — | US | disclosed |
| US-20160214951-A1 | EBI2 MODULATORS | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE | 2016-07-28 | — | — | US | disclosed |
| WO-2015048570-A2 | EBI2 MODULATORS | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2015-04-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160214951-A1 | EBI2 MODULATORS | BIRC2, HAVCR2, MAVS | PTGS2 1170/4885MAOB 4298/4885LIMK1 3629/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.