Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.43 |
| ▸ | FEN1 | P39748 | 2/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.38 |
| ▸ | SELE | P16581 | 2/20 | 0.38 |
| ▸ | GCK | P35557 | 2/20 | 0.38 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.37 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.37 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 2/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31465417 | 0.90 | KDM4E (0.40) | KMT2APARP10FEN1KDM4EMAPT | |
| SCHEMBL30438344 | 0.85 | GCK (0.44) | SCN9AGCKCARM1PRMT6MET | |
| SCHEMBL28026579 | 0.85 | GCK (0.44) | SCN9AGCKCARM1PRMT6MET | |
| SCHEMBL17242135 | 0.79 | RAB9A (0.61) | KMT2AKDM4ECARM1PRMT6RAB9A | |
| SCHEMBL726400 | 0.77 | CTNNB1 (0.57) | SMN1; SMN2USP2KMT2APARP10SCN9A | |
| SCHEMBL20176683 | 0.76 | RAB9A (0.43) | SMN1; SMN2USP2KMT2APARP10KDM4E | |
| SCHEMBL8441797 | 0.75 | KMT2A (0.60) | SMN1; SMN2USP2KMT2AKDM4EMAPT | |
| SCHEMBL27648431 | 0.74 | KDR (0.39) | FEN1KDM4EGCKCARM1PRMT6 | |
| SCHEMBL1660113 | 0.74 | MAPK14 (0.51) | KMT2ARAB9AKDR | |
| SCHEMBL3700394 | 0.74 | KDM4E (0.54) | SMN1; SMN2USP2KMT2APARP10SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101128199-B | Monocyclic heterocycles as kinase inhibitors | BRISTOL MYERS SQUIBB CO | 2013-07-24 | — | — | CN | disclosed |
| CN-101128199-A | Monocyclic heterocycles as kinase inhibitors | BRISTOL MYERS SQUIBB CO (US) | 2008-02-20 | — | — | CN | disclosed |