Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.77 |
| ▸ | KDM1A | O60341 | 8/20 | 0.66 |
| ▸ | MAOA | P21397 | 3/20 | 0.66 |
| ▸ | HPGD | P15428 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | CES1 | P23141 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13341102 | 0.84 | KDM1A (0.62) | MAPTKDM1AMAOALMNAMEN1 | |
| SCHEMBL2405184 | 0.80 | RAB9A (0.71) | MAPTHPGDLMNAMEN1KMT2A | |
| SCHEMBL8356809 | 0.80 | KDM1A (1.00) | KDM1AMAOAMEN1KMT2ANPSR1 | |
| SCHEMBL19976508 | 0.79 | MAPT (0.64) | MAPTKDM1AMAOAHPGDLMNA | |
| SCHEMBL3139618 | 0.78 | MAPT (0.70) | MAPTKDM1AMAOAHPGDLMNA | |
| SCHEMBL956179 | 0.77 | ALDH1A1 (0.64) | MAPTKDM1AMAOAHPGDLMNA | |
| SCHEMBL6554630 | 0.75 | CES1 (1.00) | MAPTMEN1KMT2AHTTALDH1A1 | |
| SCHEMBL2474197 | 0.75 | CES1 (1.00) | MAPTMEN1KMT2AHTTALDH1A1 | |
| SCHEMBL3451075 | 0.75 | KDM1A (0.83) | KDM1AMAOANPSR1 | |
| SCHEMBL16509523 | 0.75 | MAPT (0.59) | MAPTHPGDLMNAHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8993585-B2 | Cyclic amine substituted pyrimidinediamines as PKC inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2015-03-31 | — | — | US | disclosed |