Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 3/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.35 |
| ▸ | GRM5 | P41594 | 2/20 | 0.35 |
| ▸ | GABRP | O00591 | 1/20 | 0.35 |
| ▸ | GABRD | O14764 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.35 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.35 |
| ▸ | GABRE | P78334 | 1/20 | 0.35 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.35 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.35 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.35 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.35 |
| ▸ | TERT | O14746 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20085591 | 0.82 | MAPT (0.33) | CYP11B2OPRK1PDE4DMAPTNPC1 | |
| SCHEMBL14878372 | 0.79 | MAPT (0.39) | GABRG2GABRB3GABRA5GRM5GABRP | |
| SCHEMBL87094 | 0.76 | F10 (0.39) | GABRG2GABRB3GABRA5GRM5GABRP | |
| SCHEMBL14878375 | 0.74 | GABRA5 (0.39) | GABRG2GABRB3GABRA5GRM5GABRP | |
| SCHEMBL18621709 | 0.73 | MAPT (0.38) | GABRG2GABRB3GABRA5GRM5GABRP | |
| SCHEMBL18619826 | 0.73 | MAPT (0.35) | GABRG2GABRB3GABRA5GRM5GABRP | |
| SCHEMBL14878380 | 0.73 | TERT (0.35) | GABRG2GABRB3GABRA5GRM5GABRP | |
| SCHEMBL8182091 | 0.73 | BLM (0.51) | GABRG2GABRB3GABRA5CYP11B2HTT | |
| SCHEMBL20085592 | 0.73 | MAPT (0.41) | CYP11B2OPRK1PDE4DTSHRMAPT | |
| SCHEMBL14878378 | 0.73 | GABRG2 (0.51) | GABRG2GABRB3GABRA5GRM5GABRP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8993585-B2 | Cyclic amine substituted pyrimidinediamines as PKC inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2015-03-31 | — | — | US | disclosed |