Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 6/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 5/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 5/20 | 0.39 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.37 |
| ▸ | GRM5 | P41594 | 2/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.36 |
| ▸ | GABRE | P78334 | 1/20 | 0.36 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.36 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.36 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.36 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.36 |
| ▸ | TERT | O14746 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8144243 | 0.83 | GABRA5 (0.35) | GABRA5GABRG2GABRB3MAP3K5GABRA1 | |
| SCHEMBL14980087 | 0.82 | CYP19A1 (0.38) | GABRA5GABRG2GABRB3CYP11B1CYP11B2 | |
| SCHEMBL12691838 | 0.81 | GABRA5 (0.41) | GABRA5GABRG2GABRB3MAP3K5GABRA1 | |
| SCHEMBL3959344 | 0.79 | GABRG2 (0.44) | GABRA5GABRG2GABRB3MAP3K5GRM5 | |
| SCHEMBL8116517 | 0.77 | TERT (0.42) | TERTHTTCYP3A4MEN1KMT2A | |
| SCHEMBL14878379 | 0.77 | MAP3K5 (0.31) | GABRA5GABRG2GABRB3MAP3K5 | |
| SCHEMBL16601607 | 0.74 | GABRG2 (0.35) | GABRA5GABRG2GABRB3GRM5GABRA1 | |
| SCHEMBL14878378 | 0.74 | GABRG2 (0.51) | GABRA5GABRG2GABRB3GRM5GABRA1 | |
| SCHEMBL14878372 | 0.71 | MAPT (0.39) | GABRA5GABRG2GABRB3GRM5GABRA1 | |
| SCHEMBL87094 | 0.71 | F10 (0.39) | GABRA5GABRG2GABRB3GRM5GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450343-B2 | Gamma secretase modulators | SCHERING CORPORATION | 2013-05-28 | — | — | US | disclosed |
| US-8426595-B2 | Gamma secretase modulators | MERCK SHARP & DOHME LLC | 2013-04-23 | — | — | US | disclosed |