Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 2/20 | 0.67 |
| ▸ | CTSS | P25774 | 2/20 | 0.67 |
| ▸ | CTSB | P07858 | 1/20 | 0.67 |
| ▸ | CTSK | P43235 | 1/20 | 0.67 |
| ▸ | SIRT2 | Q8IXJ6 | 17/20 | 0.65 |
| ▸ | SIRT1 | Q96EB6 | 12/20 | 0.65 |
| ▸ | SIRT3 | Q9NTG7 | 11/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22599593 | 0.95 | CTSL (0.70) | CTSLCTSSCTSBCTSKSIRT2 | |
| SCHEMBL30185946 | 0.92 | CTSL (0.64) | CTSLCTSSCTSBCTSKSIRT2 | |
| SCHEMBL16407478 | 0.92 | MEN1 (0.56) | CTSLCTSSCTSBCTSKSIRT2 | |
| SCHEMBL14903029 | 0.92 | MEN1 (0.56) | CTSLCTSSCTSBCTSKSIRT2 | |
| SCHEMBL11737428 | 0.91 | CTSL (0.76) | CTSLCTSSSIRT2SIRT1SIRT3 | |
| SCHEMBL671485 | 0.91 | SIRT2 (0.65) | CTSLCTSSSIRT2SIRT1SIRT3 | |
| SCHEMBL3626824 | 0.91 | SIRT2 (0.65) | CTSLCTSSSIRT2SIRT1SIRT3 | |
| SCHEMBL10802560 | 0.90 | CTSL (0.73) | CTSLCTSSCTSBCTSKALDH1A1 | |
| SCHEMBL9113871 | 0.90 | CTSL (0.73) | CTSLCTSSCTSBCTSK | |
| SCHEMBL9306413 | 0.89 | CTSL (0.64) | CTSLCTSSSIRT2SIRT1SIRT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8993780-B2 | Amide derivatives of N-urea substituted amino acids as formyl peptide receptor like-1 (FPRL-1) receptor modulators | ALLERGAN, INC. (US) | 2015-03-31 | — | — | US | disclosed |