SCHEMBL671485

SCHEMBL671485

CCCCCCCCNC(=O)C(CO)NC(=O)OCc1ccccc1

nearest known ligand 0.65

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
SIRT2 Q8IXJ6 18/20 0.65
SIRT1 Q96EB6 13/20 0.65
SIRT3 Q9NTG7 11/20 0.65
MEN1 O00255 1/20 0.64
ALDH1A1 P00352 1/20 0.64
HPGD P15428 1/20 0.64
KMT2A Q03164 1/20 0.64
CTSL P07711 1/20 0.62
CTSS P25774 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3626824 1.00 SIRT2 (0.65) SIRT2SIRT1SIRT3MEN1ALDH1A1
SCHEMBL9306413 0.99 CTSL (0.64) SIRT2SIRT1SIRT3MEN1ALDH1A1
SCHEMBL11737428 0.91 CTSL (0.76) SIRT2SIRT1SIRT3MEN1ALDH1A1
SCHEMBL16601896 0.91 CTSL (0.67) SIRT2SIRT1SIRT3MEN1ALDH1A1
SCHEMBL20542841 0.89 CAPN1 (0.76) SIRT2SIRT1SIRT3CTSLCTSS
SCHEMBL20543115 0.89 SIRT2 (0.65) SIRT2SIRT1SIRT3MEN1ALDH1A1
SCHEMBL13870521 0.89 CAPN1 (0.76) SIRT2SIRT1SIRT3CTSLCTSS
SCHEMBL20542843 0.89 CAPN1 (0.76) SIRT2SIRT1SIRT3CTSLCTSS
SCHEMBL20543118 0.89 SIRT2 (0.65) SIRT2SIRT1SIRT3MEN1ALDH1A1
SCHEMBL7798898 0.89 SIRT2 (0.65) SIRT2SIRT1SIRT3MEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9422273-B2 Compounds act at multiple prostaglandin receptors giving a general anti-inflammatory response ALLERGAN, INC. (US) 2016-08-23 US disclosed
US-20160068520-A1 COMPOUNDS ACT AT MULTIPLE PROSTAGLANDIN RECEPTORS GIVING A GENERAL ANTI-INFLAMMATORY RESPONSE ALLERGAN, INC. 2016-03-10 US disclosed
US-9085567-B2 Compounds act at multiple prostaglandin receptors giving a general anti-inflammatory response ALLERGAN, INC. (US) 2015-07-21 US disclosed
US-9085567-B2 Compounds act at multiple prostaglandin receptors giving a general anti-inflammatory response ALLERGAN, INC. (US) 2015-07-21 US disclosed
US-20140249192-A1 COMPOUNDS ACT AT MULTIPLE PROSTAGLANDIN RECEPTORS GIVING A GENERAL ANTI-INFLAMMATORY RESPONSE ALLERGAN, INC. (US) 2014-09-04 US disclosed
US-20140249192-A1 COMPOUNDS ACT AT MULTIPLE PROSTAGLANDIN RECEPTORS GIVING A GENERAL ANTI-INFLAMMATORY RESPONSE ALLERGAN, INC. (US) 2014-09-04 US disclosed
EP-2606044-B1 COMPOUNDS ACT AT MULTIPLE PROSTAGLANDIN RECEPTORS GIVING A GENERAL ANTI-INFLAMMATORY RESPONSE ALLERGAN INC (US) 2014-06-04 EP disclosed
EP-2606044-B1 COMPOUNDS ACT AT MULTIPLE PROSTAGLANDIN RECEPTORS GIVING A GENERAL ANTI-INFLAMMATORY RESPONSE ALLERGAN INC (US) 2014-06-04 EP disclosed
EP-2699565-A1 FATTY ACID AMIDE HYDROLASE INHIBITORS FOR TREATING PAIN Allergan, Inc. (US) 2014-02-26 EP disclosed
US-8653118-B2 Compounds act at multiple prostaglandin receptors giving a general anti-inflammatory response ALLERGAN, INC. (US) 2014-02-18 US disclosed
US-20130150417-A1 COMPOUNDS ACT AT MULTIPLE PROSTAGLANDIN RECEPTORS GIVING A GENERAL ANTI-INFLAMMATORY RESPONSE ALLERGAN, INC. (US) 2013-06-13 US disclosed
WO-2012145737-A1 FATTY ACID AMIDE HYDROLASE INHIBITORS FOR TREATING ALLERGAN, INC. (US) 2012-10-26 WO disclosed
US-20120270915-A1 FATTY ACID AMIDE HYDROLASE INHIHIBITORS FOR TREATING PAIN ENERGY, UNITED STATES DEPARTMENT OF 2012-10-25 US disclosed
US-20120270915-A1 FATTY ACID AMIDE HYDROLASE INHIHIBITORS FOR TREATING PAIN ENERGY, UNITED STATES DEPARTMENT OF 2012-10-25 US disclosed
US-20120077858-A1 COMPOUNDS ACT AT MULTIPLE PROSTAGLANDIN RECEPTORS GIVING A GENERAL ANTI-INFLAMMATORY RESPONSE ALLERGAN, INC. (US) 2012-03-29 US disclosed
US-20120077858-A1 COMPOUNDS ACT AT MULTIPLE PROSTAGLANDIN RECEPTORS GIVING A GENERAL ANTI-INFLAMMATORY RESPONSE ALLERGAN, INC. (US) 2012-03-29 US disclosed
WO-2012024559-A1 COMPOUNDS ACT AT MULTIPLE PROSTAGLANDIN RECEPTORS GIVING A GENERAL ANTI-INFLAMMATORY RESPONSE ALLERGAN, INC. (US) 2012-02-23 WO disclosed
WO-2012024559-A1 COMPOUNDS ACT AT MULTIPLE PROSTAGLANDIN RECEPTORS GIVING A GENERAL ANTI-INFLAMMATORY RESPONSE ALLERGAN, INC. (US) 2012-02-23 WO disclosed
US-7700701-B2 Water-soluble polymer compound having sugar chains TOYO BOSEKI KABUSHIKI KAISHA (JP) 2010-04-20 US disclosed
US-20060287457-A1 Sugar chain-containing water-soluble polymer compound NISHIMURA, SHIN-ICHIRO, MR. (JP) 2006-12-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120077858-A1 COMPOUNDS ACT AT MULTIPLE PROSTAGLANDIN RECEPTORS GIVING A GENERAL ANTI-INFLAMMATORY RESPONSE PTGER1, PTGER4, PTGER3 SIRT2 2452/4885SIRT1 2290/4885SIRT3 1308/4885
US-20120270915-A1 FATTY ACID AMIDE HYDROLASE INHIHIBITORS FOR TREATING PAIN FAAH, FAAH2, FAH SIRT2 1226/4885SIRT1 864/4885SIRT3 1510/4885
US-20130150417-A1 COMPOUNDS ACT AT MULTIPLE PROSTAGLANDIN RECEPTORS GIVING A GENERAL ANTI-INFLAMMATORY RESPONSE PTGER1, PTGER4, PTGER3 SIRT2 2283/4885SIRT1 2294/4885SIRT3 1459/4885
US-20160068520-A1 COMPOUNDS ACT AT MULTIPLE PROSTAGLANDIN RECEPTORS GIVING A GENERAL ANTI-INFLAMMATORY RESPONSE PTGER1, PTGER4, PTGER3 SIRT2 2452/4885SIRT1 2290/4885SIRT3 1308/4885
US-20140249192-A1 COMPOUNDS ACT AT MULTIPLE PROSTAGLANDIN RECEPTORS GIVING A GENERAL ANTI-INFLAMMATORY RESPONSE PTGER1, PTGER4, PTGER3 SIRT2 2452/4885SIRT1 2290/4885SIRT3 1308/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.