Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 4/20 | 0.72 |
| ▸ | AKR1B10 | O60218 | 6/20 | 0.66 |
| ▸ | AKR1B1 | P15121 | 6/20 | 0.66 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.66 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.66 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.66 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | GMNN | O75496 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.66 |
| ▸ | EGFR | P00533 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | ESR1 | P03372 | 1/20 | 0.66 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.66 |
| ▸ | APP | P05067 | 1/20 | 0.66 |
| ▸ | LCK | P06239 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16601907 | 0.93 | AKR1B10 (0.65) | TTRAKR1B10AKR1B1ALOX5CYP3A4 | |
| SCHEMBL2602742 | 0.88 | TTR (0.69) | TTRAKR1B10AKR1B1ALOX5CYP3A4 | |
| SCHEMBL16601909 | 0.88 | CA12 (0.65) | TTRAKR1B10AKR1B1AKR1C3KDM4E | |
| SCHEMBL18534005 | 0.87 | TTR (0.74) | TTRAKR1B10AKR1B1ALOX5KDM4E | |
| SCHEMBL14113938 | 0.84 | TTR (1.00) | TTRAKR1B10AKR1B1ALOX5CYP3A4 | |
| SCHEMBL15378926 | 0.82 | TTR (0.74) | TTRAKR1B10AKR1B1ALOX5CYP3A4 | |
| SCHEMBL2602745 | 0.82 | TTR (0.74) | TTRAKR1B10AKR1B1ALOX5CYP3A4 | |
| SCHEMBL2602740 | 0.81 | AKR1B10 (0.63) | TTRAKR1B10AKR1B1ALOX5CYP3A4 | |
| SCHEMBL18534004 | 0.81 | CA12 (0.73) | TTRAKR1B10AKR1B1KDM4EALDH1A1 | |
| SCHEMBL2605865 | 0.80 | TTR (0.71) | TTRAKR1B10AKR1B1ALOX5CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9040579-B2 | Combination therapy using coenzyme Q10 and a caffeic acid-derived ester | Chemigen (US) | 2015-05-26 | — | — | US | disclosed |
| US-8993621-B2 | Caffeic acid derivatives and their use in improving neuronal cell viability | CHEMIGEN, INC. (US) | 2015-03-31 | — | — | US | disclosed |