Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 3/20 | 0.74 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.71 |
| ▸ | MET | P08581 | 5/20 | 0.62 |
| ▸ | AKR1B10 | O60218 | 3/20 | 0.60 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.60 |
| ▸ | FDPS | P14324 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | CA12 | O43570 | 1/20 | 0.55 |
| ▸ | CA4 | P22748 | 1/20 | 0.55 |
| ▸ | CA6 | P23280 | 1/20 | 0.55 |
| ▸ | CA5A | P35218 | 1/20 | 0.55 |
| ▸ | CA7 | P43166 | 1/20 | 0.55 |
| ▸ | CA9 | Q16790 | 1/20 | 0.55 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.55 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.55 |
| ▸ | APP | P05067 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16601907 | 0.93 | AKR1B10 (0.65) | TTRALOX5METAKR1B10AKR1B1 | |
| SCHEMBL15384083 | 0.92 | TTR (0.86) | TTRALOX5METAKR1B10AKR1B1 | |
| SCHEMBL18534004 | 0.87 | CA12 (0.73) | TTRAKR1B10AKR1B1FDPSKDM4E | |
| SCHEMBL16601908 | 0.87 | TTR (0.72) | TTRALOX5METAKR1B10AKR1B1 | |
| SCHEMBL20914973 | 0.86 | TTR (0.87) | TTRALOX5METAKR1B10AKR1B1 | |
| SCHEMBL20914956 | 0.86 | TTR (0.87) | TTRALOX5METAKR1B10AKR1B1 | |
| SCHEMBL29009245 | 0.86 | TTR (0.87) | TTRALOX5METAKR1B10AKR1B1 | |
| SCHEMBL14113938 | 0.85 | TTR (1.00) | TTRALOX5METAKR1B10AKR1B1 | |
| SCHEMBL20914989 | 0.83 | ALOX5 (1.00) | TTRALOX5METAKR1B10AKR1B1 | |
| SCHEMBL2602740 | 0.83 | AKR1B10 (0.63) | TTRALOX5METAKR1B10AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2629766-B1 | COMBINATION THERAPY | Chemigen (US) | 2017-02-22 | — | — | EP | disclosed |