Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B10 | O60218 | 6/20 | 0.63 |
| ▸ | AKR1B1 | P15121 | 6/20 | 0.63 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.61 |
| ▸ | TTR | P02766 | 4/20 | 0.60 |
| ▸ | MET | P08581 | 3/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | GMNN | O75496 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | ESR1 | P03372 | 1/20 | 0.55 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.55 |
| ▸ | APP | P05067 | 1/20 | 0.55 |
| ▸ | LCK | P06239 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2602742 | 0.93 | TTR (0.69) | AKR1B10AKR1B1ALOX5TTRMET | |
| SCHEMBL16601907 | 0.89 | AKR1B10 (0.65) | AKR1B10AKR1B1ALOX5TTRMET | |
| SCHEMBL2602743 | 0.86 | CA12 (0.65) | AKR1B10AKR1B1TTRMETKDM4E | |
| SCHEMBL15384083 | 0.83 | TTR (0.86) | AKR1B10AKR1B1ALOX5TTRMET | |
| SCHEMBL18534005 | 0.83 | TTR (0.74) | AKR1B10AKR1B1ALOX5TTRMET | |
| SCHEMBL16601908 | 0.81 | TTR (0.72) | AKR1B10AKR1B1ALOX5TTRMET | |
| SCHEMBL2605864 | 0.81 | ALOX5 (0.63) | AKR1B10AKR1B1ALOX5TTRMET | |
| SCHEMBL20914956 | 0.81 | TTR (0.87) | AKR1B10AKR1B1ALOX5TTRMET | |
| SCHEMBL15384911 | 0.81 | ALOX5 (0.66) | AKR1B10AKR1B1ALOX5TTRMET | |
| SCHEMBL29009245 | 0.81 | TTR (0.87) | AKR1B10AKR1B1ALOX5TTRMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9532967-B2 | Use of phenethyl caffeate derivatives in the preparation of a medicament against tumor angiogenesis | LIU JUNYI (CN) | 2017-01-03 | — | — | US | disclosed |
| US-9040579-B2 | Combination therapy using coenzyme Q10 and a caffeic acid-derived ester | Chemigen (US) | 2015-05-26 | — | — | US | disclosed |
| US-8993621-B2 | Caffeic acid derivatives and their use in improving neuronal cell viability | CHEMIGEN, INC. (US) | 2015-03-31 | — | — | US | disclosed |
| US-20130303611-A1 | USE OF PHENETHYL CAFFEATE DERIVATIVES IN THE PREPARATION OF A MEDICAMENT AGAINST TUMOR ANGIOGENESIS | LIU JUNYI (CN) | 2013-11-14 | — | — | US | disclosed |
| US-20120100122-A1 | COMBINATION THERAPY | Chemigen (US) | 2012-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130303611-A1 | USE OF PHENETHYL CAFFEATE DERIVATIVES IN THE PREPARATION OF A MEDICAMENT AGAINST TUMOR ANGIOGENESIS | NR4A3, CBR3, NCOA3 | AKR1B10 1990/4885AKR1B1 1424/4885ALOX5 560/4885 |
| US-20120100122-A1 | COMBINATION THERAPY | SLC25A20, TFAM, NDUFAB1 | AKR1B10 1036/4885AKR1B1 1115/4885ALOX5 1085/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.