Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B10 | O60218 | 6/20 | 0.65 |
| ▸ | AKR1B1 | P15121 | 6/20 | 0.65 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.64 |
| ▸ | TTR | P02766 | 4/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.57 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | GMNN | O75496 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | EGFR | P00533 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | ESR1 | P03372 | 1/20 | 0.57 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.57 |
| ▸ | APP | P05067 | 1/20 | 0.57 |
| ▸ | LCK | P06239 | 1/20 | 0.57 |
| ▸ | FYN | P06241 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18534005 | 0.93 | TTR (0.74) | AKR1B10AKR1B1ALOX5TTRKDM4E | |
| SCHEMBL16601908 | 0.93 | TTR (0.72) | AKR1B10AKR1B1ALOX5TTRCYP3A4 | |
| SCHEMBL2602740 | 0.89 | AKR1B10 (0.63) | AKR1B10AKR1B1ALOX5TTRCYP3A4 | |
| SCHEMBL16601909 | 0.85 | CA12 (0.65) | AKR1B10AKR1B1TTRKDM4EALDH1A1 | |
| SCHEMBL15384083 | 0.85 | TTR (0.86) | AKR1B10AKR1B1ALOX5TTRKDM4E | |
| SCHEMBL15384911 | 0.83 | ALOX5 (0.66) | AKR1B10AKR1B1ALOX5TTRCYP3A4 | |
| SCHEMBL2602742 | 0.81 | TTR (0.69) | AKR1B10AKR1B1ALOX5TTRCYP3A4 | |
| SCHEMBL2605864 | 0.81 | ALOX5 (0.63) | AKR1B10AKR1B1ALOX5TTRCYP3A4 | |
| SCHEMBL15384915 | 0.81 | ALOX5 (0.63) | AKR1B10AKR1B1ALOX5TTRCYP3A4 | |
| SCHEMBL3249348 | 0.81 | AKR1B10 (0.84) | AKR1B10AKR1B1ALOX5TTRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9040579-B2 | Combination therapy using coenzyme Q10 and a caffeic acid-derived ester | Chemigen (US) | 2015-05-26 | — | — | US | disclosed |
| US-8993621-B2 | Caffeic acid derivatives and their use in improving neuronal cell viability | CHEMIGEN, INC. (US) | 2015-03-31 | — | — | US | disclosed |