SCHEMBL16605159

SCHEMBL16605159

Cc1ccc(-c2ccc(-c3cccnc3)c(CF)c2)c(CCC(=O)O)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CCNC P24863 1/20 0.46
▸ CDK8 P49336 1/20 0.46
▸ PTGER1 P34995 1/20 0.41
▸ PTGER4 P35408 1/20 0.41
▸ PTGER3 P43115 1/20 0.41
▸ PTGER2 P43116 1/20 0.41
▸ KDM4E B2RXH2 2/20 0.40
▸ GFER P55789 1/20 0.40
▸ ALDH1A1 P00352 1/20 0.40
▸ PTGES O14684 2/20 0.39
▸ FFAR1 O14842 3/20 0.39
▸ FFAR4 Q5NUL3 2/20 0.39
▸ AKR1C3 P42330 1/20 0.39
▸ AKR1C2 P52895 1/20 0.39
▸ MAOA P21397 1/20 0.39
▸ MAOB P27338 1/20 0.39
▸ PPARG P37231 1/20 0.39
▸ PPARD Q03181 1/20 0.39
▸ PPARA Q07869 1/20 0.39
▸ TBXAS1 P24557 5/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16605161 0.89 SLC2A1 (0.49) CCNCCDK8PTGER1PTGER4PTGER3
SCHEMBL1808439 0.88 CCNC (0.46) CCNCCDK8PTGER1PTGER4PTGER3
SCHEMBL16605163 0.87 FFAR1 (0.50) PTGER1PTGER4PTGER3PTGER2FFAR1
SCHEMBL1805030 0.86 CYP11B2 (0.47) CCNCCDK8KDM4EALDH1A1FFAR1
SCHEMBL1811354 0.80 FFAR1 (0.50) PTGER1PTGER4PTGER3PTGER2KDM4E
SCHEMBL38659420 0.80 FFAR1 (0.50) PTGER1PTGER4PTGER3PTGER2KDM4E
SCHEMBL1817206 0.78 CCNC (0.39) CCNCCDK8TBXAS1SLC2A1
SCHEMBL1804118 0.77 CCNC (0.47) CCNCCDK8PTGER1PTGER4PTGER3
SCHEMBL1887137 0.77 FFAR1 (0.53) PTGER1PTGER4PTGER3PTGER2FFAR1
SCHEMBL1815801 0.77 CYP11B2 (0.43) CCNCCDK8KDM4EALDH1A1PPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170204197-A1 Goodpasture Antigen Binding Protein Detection and Inhibition and its Use in Diabetes FIBROSTATIN S L (ES) 2017-07-20 — — US disclosed
US-20150320730-A1 GPBP-1 inhibition and its therapeutic use FIBROSTATIN, S.L. (ES) 2015-11-12 — — US disclosed
US-9066938-B2 GPBP-1 inhibition and its therapeutic use Fibrostein, S.L. (ES) 2015-06-30 — — US disclosed
US-20150093378-A1 Goodpasture Antigen Binding Protein Detection and Inhibition and its Use in Diabetes FIBROSTATIN, S.L. (ES) 2015-04-02 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170204197-A1 Goodpasture Antigen Binding Protein Detection and Inhibition and its Use in Diabetes CD2BP2, SAP30BP, LY96 CCNC 3192/4885CDK8 2689/4885PTGER1 2343/4885
US-20150093378-A1 Goodpasture Antigen Binding Protein Detection and Inhibition and its Use in Diabetes CD2BP2, SAP30BP, LY96 CCNC 3192/4885CDK8 2689/4885PTGER1 2343/4885
US-20150320730-A1 GPBP-1 inhibition and its therapeutic use ABCC1, ABCC8, ABCB1 CCNC 715/4885CDK8 861/4885PTGER1 888/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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