SCHEMBL1808439

SCHEMBL1808439

O=C(O)CCc1cc(O)ccc1-c1ccc(-c2cccnc2)c(CF)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CCNC P24863 1/20 0.46
▸ CDK8 P49336 1/20 0.46
▸ CYP11B1 P15538 3/20 0.43
▸ CYP11B2 P19099 3/20 0.43
▸ CYP17A1 P05093 2/20 0.43
▸ CYP3A4 P08684 2/20 0.43
▸ PTGER4 P35408 4/20 0.42
▸ PTGER3 P43115 4/20 0.42
▸ PTGER1 P34995 3/20 0.42
▸ PTGER2 P43116 3/20 0.42
▸ CYP19A1 P11511 1/20 0.41
▸ TBXAS1 P24557 6/20 0.39
▸ AKR1C3 P42330 1/20 0.37
▸ AKR1C2 P52895 1/20 0.37
▸ NPC1 O15118 1/20 0.37
▸ MAPT P10636 1/20 0.37
▸ RAB9A P51151 1/20 0.37
▸ MKNK1 Q9BUB5 1/20 0.37
▸ MKNK2 Q9HBH9 1/20 0.37
▸ EGLN3 Q9H6Z9 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1804118 0.90 CCNC (0.47) CCNCCDK8CYP11B1CYP11B2CYP17A1
SCHEMBL16605159 0.88 CCNC (0.46) CCNCCDK8PTGER4PTGER3PTGER1
SCHEMBL1801505 0.86 CCNC (0.44) CCNCCDK8CYP11B1CYP11B2CYP17A1
SCHEMBL1817206 0.85 CCNC (0.39) CCNCCDK8CYP11B1CYP11B2CYP17A1
SCHEMBL1805030 0.85 CYP11B2 (0.47) CCNCCDK8CYP11B1CYP11B2CYP17A1
SCHEMBL17615828 0.84 ERN1 (0.48) CCNCCDK8CYP11B1CYP11B2CYP17A1
SCHEMBL1811354 0.83 FFAR1 (0.50) PTGER4PTGER3PTGER1PTGER2AKR1C3
SCHEMBL38659420 0.83 FFAR1 (0.50) PTGER4PTGER3PTGER1PTGER2AKR1C3
SCHEMBL38659563 0.81 RXRA (0.44) PTGER4PTGER3PTGER1PTGER2AKR1C3
SCHEMBL1891430 0.81 RXRA (0.44) PTGER4PTGER3PTGER1PTGER2AKR1C3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026099533-A1 TREATMENT OF ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS) WITH GPBP1 INHIBITORS UNIVERSITAT DE VALÈNCIA (ES) 2026-05-15 — — WO claimed
WO-2016107906-A1 METHODS FOR INHIBITING MESENCHYMAL PHENOTYPE AFTER EPITHELIAL-TO-MESENCHYMAL TRANSITION FIBROSTATIN, S.L. (ES) 2016-07-07 — — WO claimed
US-20160184274-A1 Methods for inhibiting mesenchymal phenotype after epithelial-to-mesenchymal transition UNIVERSITAT DE VALENCIA (ES) 2016-06-30 — — US claimed
US-9199936-B2 GPBP inhibition using Q2 peptidomimetics Fibrostatin Sociedad Limitada (ES) 2015-12-01 — — US claimed
EP-2496544-B1 GPBP INHIBITION USING Q2 PEPTIDOMIMETICS FIBROSTATIN S L (SE) 2014-08-20 — — EP claimed
US-20140080852-A1 GPBP inhibition using Q2 peptidomimetics FIBROSTATIN, S.L. (ES) 2014-03-20 — — US claimed
EP-2496544-A1 GPBP INHIBITION USING Q2 PEPTIDOMIMETICS Fibrostatin, S.L. (SE) 2012-09-12 — — EP claimed
WO-2011054530-A1 GPBP INHIBITION USING Q2 PEPTIDOMIMETICS FIBROSTATIN, S.L. (ES) 2011-05-12 — — WO claimed
US-20110105545-A1 GPBP inhibition using Q2 peptidomimetics FIBROSTATIN, S.L. (ES) 2011-05-05 — — US claimed
WO-2026099533-A1 TREATMENT OF ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS) WITH GPBP1 INHIBITORS UNIVERSITAT DE VALÈNCIA (ES) 2026-05-15 — — WO disclosed
US-10544083-B2 GPBP inhibition using Q2 peptidomimetics UNIVERSITAT DE VALÈNCIA (ES) 2020-01-28 — — US disclosed
US-10544083-B2 GPBP inhibition using Q2 peptidomimetics UNIVERSITAT DE VALÈNCIA (ES) 2020-01-28 — — US disclosed
US-20180179139-A1 GPBP inhibition using Q2 peptidomimetics FIBROSTATIN, S.L. (ES) 2018-06-28 — — US disclosed
US-20180179139-A1 GPBP inhibition using Q2 peptidomimetics FIBROSTATIN, S.L. (ES) 2018-06-28 — — US disclosed
EP-2496544-A1 GPBP INHIBITION USING Q2 PEPTIDOMIMETICS Fibrostatin, S.L. (SE) 2012-09-12 — — EP disclosed
WO-2011054530-A1 GPBP INHIBITION USING Q2 PEPTIDOMIMETICS FIBROSTATIN, S.L. (ES) 2011-05-12 — — WO disclosed
WO-2011054530-A1 GPBP INHIBITION USING Q2 PEPTIDOMIMETICS FIBROSTATIN, S.L. (ES) 2011-05-12 — — WO disclosed
US-20110105545-A1 GPBP inhibition using Q2 peptidomimetics FIBROSTATIN, S.L. (ES) 2011-05-05 — — US disclosed
US-20110105545-A1 GPBP inhibition using Q2 peptidomimetics FIBROSTATIN, S.L. (ES) 2011-05-05 — — US disclosed
US-20110105545-A1 GPBP inhibition using Q2 peptidomimetics FIBROSTATIN, S.L. (ES) 2011-05-05 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10544083-B2 GPBP inhibition using Q2 peptidomimetics HSP90B1, ERP44, HSPA5 CCNC 3050/4885CDK8 3322/4885CYP11B1 2299/4885
US-20140080852-A1 GPBP inhibition using Q2 peptidomimetics HSP90B1, ERP44, HSPA5 CCNC 3050/4885CDK8 3322/4885CYP11B1 2299/4885
US-20110105545-A1 GPBP inhibition using Q2 peptidomimetics HSP90B1, ERP44, HSPA5 CCNC 3050/4885CDK8 3322/4885CYP11B1 2299/4885
US-20160184274-A1 Methods for inhibiting mesenchymal phenotype after epithelial-to-mesenchymal transition VIM, EPCAM, CDH1 CCNC 2396/4885CDK8 1983/4885CYP11B1 4835/4885
US-20180179139-A1 GPBP inhibition using Q2 peptidomimetics HSP90B1, ERP44, HSPA5 CCNC 3050/4885CDK8 3322/4885CYP11B1 2299/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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