Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | ABL1 | P00519 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 7/20 | 0.57 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | OGA | O60502 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16607122 | 0.90 | KDM4E (0.67) | MEN1KMT2AABL1LMNAKDM4E | |
| SCHEMBL16607309 | 0.89 | LMNA (0.61) | MEN1KMT2AL3MBTL1ABL1LMNA | |
| SCHEMBL16607214 | 0.86 | LMNA (0.59) | MEN1KMT2ALMNAKDM4EHTT | |
| SCHEMBL16607222 | 0.85 | MAPT (0.78) | MEN1KMT2AL3MBTL1ABL1LMNA | |
| SCHEMBL21382494 | 0.80 | LMNA (0.59) | MEN1KMT2AL3MBTL1ABL1LMNA | |
| SCHEMBL2753858 | 0.78 | ABL1 (0.67) | MEN1KMT2AL3MBTL1ABL1LMNA | |
| SCHEMBL16607230 | 0.78 | ABL1 (0.67) | MEN1KMT2AL3MBTL1ABL1LMNA | |
| SCHEMBL31237167 | 0.78 | NPC1 (0.63) | MEN1KMT2AL3MBTL1ABL1LMNA | |
| SCHEMBL22205273 | 0.77 | LMNA (0.59) | MEN1KMT2AL3MBTL1ABL1LMNA | |
| SCHEMBL21382270 | 0.77 | LMNA (0.56) | MEN1KMT2AL3MBTL1ABL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10729695-B2 | Amino, amido and heterocyclic compounds as modulators of RAGE activity and uses thereof | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2020-08-04 | — | — | US | disclosed |
| US-10265320-B2 | Amino, amido and heterocyclic compounds as modulators of rage activity and uses thereof | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2019-04-23 | — | — | US | disclosed |
| US-20160263125-A1 | AMINO, AMIDO AND HETEROCYCLIC COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF | NEW YORK UNIVERSITY | 2016-09-15 | — | — | US | disclosed |
| US-9364472-B2 | Amino, Amido and heterocyclic compounds as modulators of RAGE activity and uses thereof | NEW YORK UNIVERSITY (US) | 2016-06-14 | — | — | US | disclosed |
| US-9353078-B2 | Amino, amido and heterocyclic compounds as modulators of rage activity and uses thereof | NEW YORK UNIVERSITY (US) | 2016-05-31 | — | — | US | disclosed |
| US-20160101096-A1 | AMINO, AMIDO AND HETEROCYCLIC COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF | NEW YORK UNIVERSITY | 2016-04-14 | — | — | US | disclosed |
| WO-2015050984-A1 | AMINO, AMIDO, AND HETEROCYCLIC COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF | NEW YORK UNIVERSITY (US) | 2015-04-09 | — | — | WO | disclosed |
| US-20150094307-A1 | AMINO, AMIDO AND HETEROCYCLIC COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK | 2015-04-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150094307-A1 | AMINO, AMIDO AND HETEROCYCLIC COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF | AGER, IAPP, GPR119 | MEN1 2624/4885KMT2A 4609/4885L3MBTL1 2912/4885 |
| US-10729695-B2 | Amino, amido and heterocyclic compounds as modulators of RAGE activity and uses thereof | AGER, IAPP, GPR119 | MEN1 2624/4885KMT2A 4609/4885L3MBTL1 2912/4885 |
| US-20160263125-A1 | AMINO, AMIDO AND HETEROCYCLIC COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF | AGER, IAPP, GPR119 | MEN1 2624/4885KMT2A 4609/4885L3MBTL1 2912/4885 |
| US-20160101096-A1 | AMINO, AMIDO AND HETEROCYCLIC COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF | AGER, IAPP, GPR119 | MEN1 2624/4885KMT2A 4609/4885L3MBTL1 2912/4885 |
| US-10265320-B2 | Amino, amido and heterocyclic compounds as modulators of rage activity and uses thereof | AGER, IAPP, GPR119 | MEN1 2624/4885KMT2A 4609/4885L3MBTL1 2912/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.