Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.78 |
| ▸ | LMNA | P02545 | 4/20 | 0.78 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.71 |
| ▸ | HTT | P42858 | 3/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.71 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.71 |
| ▸ | SCD | O00767 | 1/20 | 0.63 |
| ▸ | ABL1 | P00519 | 4/20 | 0.63 |
| ▸ | MEN1 | O00255 | 5/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | NPY1R | P25929 | 1/20 | 0.55 |
| ▸ | NPY2R | P49146 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | OGA | O60502 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16607230 | 0.88 | ABL1 (0.67) | MAPTLMNASMN1; SMN2HTTCYP1A2 | |
| SCHEMBL16607181 | 0.85 | MEN1 (0.61) | MAPTLMNASMN1; SMN2HTTCYP1A2 | |
| SCHEMBL16607214 | 0.81 | LMNA (0.59) | MAPTLMNASMN1; SMN2HTTCYP1A2 | |
| SCHEMBL16607175 | 0.80 | GPER1 (0.55) | MAPTLMNASMN1; SMN2HTTCYP1A2 | |
| SCHEMBL16607309 | 0.78 | LMNA (0.61) | MAPTLMNASMN1; SMN2HTTCYP1A2 | |
| SCHEMBL16607122 | 0.78 | KDM4E (0.67) | MAPTLMNASMN1; SMN2HTTCYP1A2 | |
| SCHEMBL4284162 | 0.76 | MAPT (0.61) | MAPTLMNASMN1; SMN2HTTCYP1A2 | |
| Hydrochloric Acid SCHEMBL4279963 | 0.76 | MAPT (0.60) | MAPTLMNASMN1; SMN2HTTCYP1A2 | |
| SCHEMBL2753995 | 0.74 | MAPT (0.76) | MAPTLMNASMN1; SMN2HTTCYP1A2 | |
| SCHEMBL2753293 | 0.74 | LMNA (0.69) | MAPTLMNASMN1; SMN2HTTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10729695-B2 | Amino, amido and heterocyclic compounds as modulators of RAGE activity and uses thereof | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2020-08-04 | — | — | US | disclosed |
| US-10265320-B2 | Amino, amido and heterocyclic compounds as modulators of rage activity and uses thereof | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2019-04-23 | — | — | US | disclosed |
| US-20160263125-A1 | AMINO, AMIDO AND HETEROCYCLIC COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF | NEW YORK UNIVERSITY | 2016-09-15 | — | — | US | disclosed |
| US-9364472-B2 | Amino, Amido and heterocyclic compounds as modulators of RAGE activity and uses thereof | NEW YORK UNIVERSITY (US) | 2016-06-14 | — | — | US | disclosed |
| US-9353078-B2 | Amino, amido and heterocyclic compounds as modulators of rage activity and uses thereof | NEW YORK UNIVERSITY (US) | 2016-05-31 | — | — | US | disclosed |
| US-20160101096-A1 | AMINO, AMIDO AND HETEROCYCLIC COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF | NEW YORK UNIVERSITY | 2016-04-14 | — | — | US | disclosed |
| WO-2015050984-A1 | AMINO, AMIDO, AND HETEROCYCLIC COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF | NEW YORK UNIVERSITY (US) | 2015-04-09 | — | — | WO | disclosed |
| US-20150094307-A1 | AMINO, AMIDO AND HETEROCYCLIC COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK | 2015-04-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150094307-A1 | AMINO, AMIDO AND HETEROCYCLIC COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF | AGER, IAPP, GPR119 | MAPT 1914/4885LMNA 1219/4885SMN1; SMN2 1119/4885 |
| US-10729695-B2 | Amino, amido and heterocyclic compounds as modulators of RAGE activity and uses thereof | AGER, IAPP, GPR119 | MAPT 1914/4885LMNA 1219/4885SMN1; SMN2 1119/4885 |
| US-20160263125-A1 | AMINO, AMIDO AND HETEROCYCLIC COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF | AGER, IAPP, GPR119 | MAPT 1914/4885LMNA 1219/4885SMN1; SMN2 1119/4885 |
| US-20160101096-A1 | AMINO, AMIDO AND HETEROCYCLIC COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF | AGER, IAPP, GPR119 | MAPT 1914/4885LMNA 1219/4885SMN1; SMN2 1119/4885 |
| US-10265320-B2 | Amino, amido and heterocyclic compounds as modulators of rage activity and uses thereof | AGER, IAPP, GPR119 | MAPT 1914/4885LMNA 1219/4885SMN1; SMN2 1119/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.