SCHEMBL1660720

SCHEMBL1660720

OC1Cc2ccccc2O[C@H]1c1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.48
KDM4E B2RXH2 2/20 0.48
HSD17B10 Q99714 2/20 0.48
MAPK1 P28482 2/20 0.48
ALDH1A1 P00352 1/20 0.48
MAPT P10636 1/20 0.48
ALOX15 P16050 1/20 0.48
HSP90AB1 P08238 1/20 0.47
SYNJ2 O15056 1/20 0.43
PTGS1 P23219 1/20 0.43
PTGS2 P35354 1/20 0.43
MEN1 O00255 1/20 0.43
KMT2A Q03164 1/20 0.43
GABRA1 P14867 1/20 0.43
GABRB2 P47870 1/20 0.43
MAOB P27338 6/20 0.42
ADORA3 P0DMS8 1/20 0.42
AR P10275 1/20 0.42
CYP19A1 P11511 1/20 0.42
SLC18A3 Q16572 3/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9019698 1.00 CYP3A4 (0.48) CYP3A4KDM4EHSD17B10MAPK1ALDH1A1
SCHEMBL30775720 1.00 CYP3A4 (0.48) CYP3A4KDM4EHSD17B10MAPK1ALDH1A1
SCHEMBL30775787 1.00 CYP3A4 (0.48) CYP3A4KDM4EHSD17B10MAPK1ALDH1A1
SCHEMBL29355417 1.00 CYP3A4 (0.48) CYP3A4KDM4EHSD17B10MAPK1ALDH1A1
SCHEMBL460037 1.00 CYP3A4 (0.48) CYP3A4KDM4EHSD17B10MAPK1ALDH1A1
SCHEMBL1659938 1.00 CYP3A4 (0.48) CYP3A4KDM4EHSD17B10MAPK1ALDH1A1
SCHEMBL30775723 1.00 CYP3A4 (0.48) CYP3A4KDM4EHSD17B10MAPK1ALDH1A1
SCHEMBL18746282 1.00 CYP3A4 (0.48) CYP3A4KDM4EHSD17B10MAPK1ALDH1A1
SCHEMBL460038 1.00 CYP3A4 (0.48) CYP3A4KDM4EHSD17B10MAPK1ALDH1A1
SCHEMBL1659934 1.00 CYP3A4 (0.48) CYP3A4KDM4EHSD17B10MAPK1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220125814-A1 CANCER COMBINATION THERAPIES UTILIZING A NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE INHIBITOR IN COMBINATION WITH A NICOTINAMIDE ADENINE DINUCLEOTIDE SALVAGE PATHWAY PRECURSOR FRED HUTCHINSON CANCER RESEARCH CENTER (US) 2022-04-28 US claimed
WO-2020191359-A1 CANCER COMBINATION THERAPIES UTILIZING A NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE INHIBITOR IN COMBINATION WITH A NICOTINAMIDE ADENINE DINUCLEOTIDE SALVAGE PATHWAY PRECURSOR FRED HUTCHINSON CANCER RESEARCH CENTER (US) 2020-09-24 WO claimed
US-20180200275-A1 METHOD AND THE USE TO IMPROVE ORAL ABSORPTION OF NICOTINAMIDE AND NICOTINAMIDE RIBOSIDE Better Standing Company Inc. (US) 2018-07-19 US claimed
US-20240216412-A1 OXIDIZED NICOTINAMIDE ADENINE DINUCLEOTIDE (NAD+) PRECURSOR TREATMENT FOR HEART FAILURE ALLEVIATION INDEPENDENT OF MITOCHONDRIAL PROTEIN DEACETYLATION UNIVERSITY OF WASHINGTON (US) 2024-07-04 US disclosed
US-20230263817-A1 HIGH DOSE NICOTINAMIDE ADENINE DINUCLEOTIDE (NAD) PRECURSOR REGIMENS FOR REDUCTION OF INFLAMMATION IN HUMAN PATIENTS WITH PREEXISTING INFLAMMATION UNIVERSITY OF WASHINGTON (US) 2023-08-24 US disclosed
US-20220125814-A1 CANCER COMBINATION THERAPIES UTILIZING A NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE INHIBITOR IN COMBINATION WITH A NICOTINAMIDE ADENINE DINUCLEOTIDE SALVAGE PATHWAY PRECURSOR FRED HUTCHINSON CANCER RESEARCH CENTER (US) 2022-04-28 US disclosed
WO-2020191359-A1 CANCER COMBINATION THERAPIES UTILIZING A NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE INHIBITOR IN COMBINATION WITH A NICOTINAMIDE ADENINE DINUCLEOTIDE SALVAGE PATHWAY PRECURSOR FRED HUTCHINSON CANCER RESEARCH CENTER (US) 2020-09-24 WO disclosed
EP-2488010-A1 MANIPULATION OF FLAVONOID BIOSYNTHETIC PATHWAY Agriculture Victoria Services Pty Ltd (AU) 2012-08-22 EP disclosed
WO-2011044632-A1 MANIPULATION OF FLAVONOID BIOSYNTHETIC PATHWAY AGRICULTURE VICTORIA SERVICES PTY LTD (AU) 2011-04-21 WO disclosed
US-20080070874-A1 using retinoid or tetracycline as bactericide, benzoyl peroxide as metalloproteinases (MMPs) and neutrophil elastase inhibitors; antiscarring agents; reduction in procollagen biosynthesis THE REGENTS OF THE UNIVERSITY OF MICHIGAN 2008-03-20 US disclosed
US-7268148-B2 Compositions and methods for use against acne-induced inflammation and dermal matrix-degrading enzymes REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2007-09-11 US disclosed
US-20040235950-A1 Compositions and methods for use against acne-induced inflammation and dermal matrix-degrading enzymes REGENTS OF THE UNIVERSITY OF MICHIGAN, THE 2004-11-25 US disclosed
EP-1284721-A2 COMPOSITIONS AND METHODS FOR USE AGAINST ACNE-INDUCED INFLAMMATION AND DERMAL MATRIX-DEGRADING ENZYMES THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2003-02-26 EP disclosed
US-20020106339-A1 Compositions and methods using direct MMP inhibitors for inhibiting photoaging of skin FISHER GARY J (US) 2002-08-08 US disclosed
US-6365630-B1 Compositions and methods for inhibiting photoaging of skin REGENTS OF THE UNIVERSITY OF MICHIGAN 2002-04-02 US disclosed
WO-2001089502-A2 COMPOSITIONS AND METHODS FOR USE AGAINST ACNE-INDUCED INFLAMMATION AND DERMAL MATRIX-DEGRADING ENZYMES THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2001-11-29 WO disclosed
US-6130254-A Methods for inhibiting photoaging of skin REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2000-10-10 US disclosed
EP-0998251-A4 COMPOSITIONS AND METHODS FOR INHIBITING PHOTOAGING OF SKIN UNIV MICHIGAN (US) 2000-08-30 EP disclosed
EP-0998251-A2 COMPOSITIONS AND METHODS FOR INHIBITING PHOTOAGING OF SKIN THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2000-05-10 EP disclosed
WO-1998055075-A2 COMPOSITIONS AND METHODS FOR INHIBITING PHOTOAGING OF SKIN REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 1998-12-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230263817-A1 HIGH DOSE NICOTINAMIDE ADENINE DINUCLEOTIDE (NAD) PRECURSOR REGIMENS FOR REDUCTION OF INFLAMMATION IN HUMAN PATIENTS WITH PREEXISTING INFLAMMATION NAMPT, NNT, NQO1 CYP3A4 421/4885KDM4E 4593/4885HSD17B10 1135/4885
US-20180200275-A1 METHOD AND THE USE TO IMPROVE ORAL ABSORPTION OF NICOTINAMIDE AND NICOTINAMIDE RIBOSIDE SIRT6, NADK, SIRT1 CYP3A4 1028/4885KDM4E 4762/4885HSD17B10 3067/4885
US-20220125814-A1 CANCER COMBINATION THERAPIES UTILIZING A NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE INHIBITOR IN COMBINATION WITH A NICOTINAMIDE ADENINE DINUCLEOTIDE SALVAGE PATHWAY PRECURSOR NAMPT, NADK, NNT CYP3A4 3656/4885KDM4E 3102/4885HSD17B10 2494/4885
US-20240216412-A1 OXIDIZED NICOTINAMIDE ADENINE DINUCLEOTIDE (NAD+) PRECURSOR TREATMENT FOR HEART FAILURE ALLEVIATION INDEPENDENT OF MITOCHONDRIAL PROTEIN DEACETYLATION NAMPT, SIRT3, NDUFAB1 CYP3A4 4074/4885KDM4E 3681/4885HSD17B10 874/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.