Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | HTR6 | P50406 | 2/20 | 0.53 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.49 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.49 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | HTR1D | P28221 | 1/20 | 0.46 |
| ▸ | HTR1B | P28222 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12479182 | 0.91 | HTR2A (0.58) | HTR2AMEN1KMT2AHTR6HCRTR2 | |
| SCHEMBL12479624 | 0.79 | MAPT (0.52) | HTR2AMEN1KMT2AHTR6CYP1A2 | |
| SCHEMBL16612771 | 0.79 | ADRB2 (0.50) | MEN1KMT2AHTR6HCRTR2HCRTR1 | |
| SCHEMBL12479701 | 0.77 | ADRB2 (0.63) | MEN1KMT2AHTR6HCRTR2HCRTR1 | |
| SCHEMBL12479085 | 0.75 | MPO (0.56) | HTR2AKMT2AHTR1ATRPM8 | |
| SCHEMBL12479723 | 0.75 | MTNR1A (0.50) | MEN1KMT2AHCRTR2HCRTR1MTNR1A | |
| SCHEMBL12479224 | 0.75 | HTR2A (0.58) | HTR2AMEN1KMT2AHTR6HCRTR2 | |
| SCHEMBL29874859 | 0.75 | HTR2A (1.00) | HTR2AMEN1KMT2AHTR6MTNR1A | |
| SCHEMBL379337 | 0.75 | HTR2A (1.00) | HTR2AMEN1KMT2AHTR6MTNR1A | |
| SCHEMBL32669432 | 0.73 | HTR2A (0.63) | HTR2AMEN1KMT2AHTR6MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2675801-B1 | NOVEL PYRAZOLE AND IMIDAZOLE DERIVATIVES USEFUL AS OREXIN ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2015-04-08 | — | — | EP | disclosed |