Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 1/20 | 0.45 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 3/20 | 0.36 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.36 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.35 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 7/20 | 0.35 |
| ▸ | CDK2 | P24941 | 7/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 7/20 | 0.35 |
| ▸ | AURKA | O14965 | 3/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | STAT6 | P42226 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16612710 | 0.81 | KDM4E (0.49) | HCRTR2PDE10ASYK | |
| SCHEMBL16612738 | 0.79 | HCRTR2 (0.36) | HCRTR2SYKZAP70CCNA2CDK2 | |
| SCHEMBL16612690 | 0.79 | HCRTR2 (0.35) | HCRTR2SYKCCNA2CDK2CCNA1 | |
| SCHEMBL16612643 | 0.79 | HCRTR1 (0.39) | HCRTR2SYK | |
| SCHEMBL12479212 | 0.78 | FDPS (0.45) | FDPSHCRTR2PDE10ASYKZAP70 | |
| SCHEMBL16612872 | 0.77 | HCRTR2 (0.41) | HCRTR2SYKCCNA2CDK2CCNA1 | |
| SCHEMBL16612797 | 0.76 | HCRTR2 (0.40) | HCRTR2 | |
| SCHEMBL16612825 | 0.75 | HCRTR2 (0.41) | HCRTR2 | |
| SCHEMBL16612841 | 0.72 | MAPT (0.40) | HCRTR2 | |
| SCHEMBL16613039 | 0.71 | MEN1 (0.46) | HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2675801-B1 | NOVEL PYRAZOLE AND IMIDAZOLE DERIVATIVES USEFUL AS OREXIN ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2015-04-08 | — | — | EP | claimed |