Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | IKBKB | O14920 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.30 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.30 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16613039 | 0.81 | MEN1 (0.46) | HCRTR1HCRTR2POLBTDP1MEN1 | |
| SCHEMBL16612683 | 0.79 | FDPS (0.45) | HCRTR2SYK | |
| SCHEMBL16612877 | 0.79 | HCRTR2 (0.35) | HCRTR2SYKAURKB | |
| SCHEMBL16612923 | 0.77 | LTA4H (0.43) | HCRTR1HCRTR2L3MBTL1 | |
| SCHEMBL16612712 | 0.74 | HCRTR2 (0.38) | HCRTR1HCRTR2POLBTDP1 | |
| SCHEMBL16612710 | 0.73 | KDM4E (0.49) | HCRTR2POLBMEN1MAPTKMT2A | |
| SCHEMBL16612782 | 0.73 | HCRTR2 (0.39) | HCRTR1HCRTR2 | |
| SCHEMBL16613011 | 0.71 | HCRTR2 (0.36) | HCRTR1HCRTR2 | |
| SCHEMBL16612850 | 0.71 | HCRTR2 (0.38) | HCRTR1HCRTR2MAPT | |
| SCHEMBL16612857 | 0.70 | MTNR1A (0.44) | TDP1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2675801-B1 | NOVEL PYRAZOLE AND IMIDAZOLE DERIVATIVES USEFUL AS OREXIN ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2015-04-08 | — | — | EP | claimed |