Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | NNMT | P40261 | 3/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.31 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.31 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.31 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16613011 | 0.86 | HCRTR2 (0.36) | HCRTR2KDM1ANNMTHCRTR1HTR1A | |
| SCHEMBL16612877 | 0.84 | HCRTR2 (0.35) | HCRTR2 | |
| SCHEMBL16612990 | 0.82 | HCRTR2 (0.39) | HCRTR2ALDH1A1HCRTR1 | |
| SCHEMBL16612782 | 0.80 | HCRTR2 (0.39) | HCRTR2KDM1AHCRTR1HTR1A | |
| SCHEMBL16612841 | 0.80 | MAPT (0.40) | HCRTR2KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL16612935 | 0.80 | HCRTR2 (0.38) | HCRTR2HCRTR1 | |
| SCHEMBL16613039 | 0.77 | MEN1 (0.46) | HCRTR2KDM4EALDH1A1HSD17B10HCRTR1 | |
| SCHEMBL16612786 | 0.74 | PKM (0.54) | HCRTR2ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL16612712 | 0.74 | HCRTR2 (0.38) | HCRTR2ALDH1A1NNMTHCRTR1LMNA | |
| SCHEMBL16612738 | 0.73 | HCRTR2 (0.36) | HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2675801-B1 | NOVEL PYRAZOLE AND IMIDAZOLE DERIVATIVES USEFUL AS OREXIN ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2015-04-08 | — | — | EP | disclosed |