Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16612935 | 0.76 | HCRTR2 (0.38) | HCRTR2KMT2A | |
| SCHEMBL16612990 | 0.76 | HCRTR2 (0.39) | PKMHCRTR2ALDH1A1 | |
| SCHEMBL16613011 | 0.74 | HCRTR2 (0.36) | HCRTR2 | |
| SCHEMBL16612850 | 0.74 | HCRTR2 (0.38) | HCRTR2MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL16612712 | 0.74 | HCRTR2 (0.38) | HCRTR2SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL16612782 | 0.74 | HCRTR2 (0.39) | HCRTR2 | |
| SCHEMBL16612877 | 0.72 | HCRTR2 (0.35) | HCRTR2 | |
| SCHEMBL16612787 | 0.71 | PKM (0.49) | PKMNPC1HCRTR2RAB9AMAPT | |
| SCHEMBL16612857 | 0.71 | MTNR1A (0.44) | PKMNPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL16612828 | 0.71 | SIRT2 (0.39) | HCRTR2SMN1; SMN2NPSR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2675801-B1 | NOVEL PYRAZOLE AND IMIDAZOLE DERIVATIVES USEFUL AS OREXIN ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2015-04-08 | — | — | EP | disclosed |