Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 2/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | POLQ | O75417 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 3/20 | 0.31 |
| ▸ | SYK | P43405 | 2/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16612782 | 0.84 | HCRTR2 (0.39) | HCRTR2HCRTR1GRM5 | |
| SCHEMBL16612990 | 0.84 | HCRTR2 (0.39) | HCRTR2HCRTR1 | |
| SCHEMBL16612850 | 0.80 | HCRTR2 (0.38) | HCRTR2HCRTR1 | |
| SCHEMBL16612877 | 0.78 | HCRTR2 (0.35) | HCRTR2SYK | |
| SCHEMBL16612712 | 0.78 | HCRTR2 (0.38) | HCRTR2HCRTR1 | |
| SCHEMBL16612786 | 0.76 | PKM (0.54) | HCRTR2KMT2A | |
| SCHEMBL16613039 | 0.74 | MEN1 (0.46) | HCRTR2HCRTR1KMT2A | |
| SCHEMBL16613011 | 0.73 | HCRTR2 (0.36) | HCRTR2HCRTR1GRM5 | |
| SCHEMBL16612772 | 0.72 | KMT2A (0.46) | HCRTR2HCRTR1SYKKMT2A | |
| SCHEMBL16612857 | 0.72 | MTNR1A (0.44) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2675801-B1 | NOVEL PYRAZOLE AND IMIDAZOLE DERIVATIVES USEFUL AS OREXIN ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2015-04-08 | — | — | EP | claimed |