Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 1/20 | 0.36 |
| ▸ | PYGM | P11217 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | EPAS1 | Q99814 | 5/20 | 0.34 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.32 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9238137 | 0.82 | SSTR4 (0.35) | PYGLPYGMCCKBR | |
| SCHEMBL6832251 | 0.79 | RIPK1 (0.39) | PYGLPYGMRIPK1EPAS1KDM4D | |
| SCHEMBL31448421 | 0.76 | PYGL (0.43) | PYGLPYGMSLC6A4HRH3RIPK1 | |
| SCHEMBL9886180 | 0.75 | EPHX2 (0.36) | PYGLPYGMKDM4D | |
| SCHEMBL3802539 | 0.74 | CFTR (0.38) | PYGLPYGMSLC6A4HRH3RIPK1 | |
| SCHEMBL3774235 | 0.73 | HIF1A (0.36) | PYGLPYGM | |
| SCHEMBL5132913 | 0.71 | KYAT1 (0.37) | RIPK1EPAS1MGLL | |
| SCHEMBL3777460 | 0.70 | RIPK1 (0.36) | RIPK1 | |
| SCHEMBL3777420 | 0.70 | CCKBR (0.39) | PYGLPYGMSLC6A4RIPK1CCKBR | |
| SCHEMBL3779542 | 0.70 | MEN1 (0.32) | PYGLPYGMTP53CCKBR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2443092-B1 | BICYCLIC AND TRICYCLIC COMPOUNDS AS KAT II INHIBITORS | PFIZER (US) | 2015-04-08 | — | — | EP | disclosed |