Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | NR3C1 | P04150 | 19/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20169814 | 1.00 | KDM4E (0.53) | KDM4EMEN1KMT2ANPSR1NR3C1 | |
| SCHEMBL16614004 | 0.83 | NR3C1 (0.42) | KDM4EMEN1KMT2ANPSR1NR3C1 | |
| SCHEMBL20068222 | 0.83 | NR3C1 (0.42) | KDM4EMEN1KMT2ANPSR1NR3C1 | |
| SCHEMBL20169789 | 0.80 | KDM4E (0.38) | KDM4EMEN1KMT2ANPSR1 | |
| SCHEMBL20068223 | 0.79 | NR3C1 (0.41) | KDM4EMEN1KMT2ANPSR1NR3C1 | |
| SCHEMBL20068224 | 0.79 | NR3C1 (0.39) | KDM4EMEN1KMT2ANPSR1NR3C1 | |
| SCHEMBL20068225 | 0.79 | NR3C1 (0.39) | KDM4EMEN1KMT2ANPSR1NR3C1 | |
| SCHEMBL20068185 | 0.79 | NR3C1 (0.40) | KDM4EMEN1KMT2ANPSR1NR3C1 | |
| SCHEMBL20068220 | 0.79 | NR3C1 (0.40) | KDM4EMEN1KMT2ANPSR1NR3C1 | |
| SCHEMBL20068221 | 0.79 | NR3C1 (0.52) | KDM4EMEN1KMT2ANPSR1NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10954265-B2 | Structures and mechanism for the design of highly potent glucocorticoids | VAN ANDEL RESEARCH INSTITUTE (US) | 2021-03-23 | — | — | US | disclosed |
| US-20190263853-A1 | STRUCTURES AND MECHANISM FOR THE DESIGN OF HIGHLY POTENT GLUCOCORTICOIDS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2019-08-29 | — | — | US | disclosed |
| EP-3049089-B1 | HIGHLY POTENT GLUCOCORTICOIDS | VAN ANDEL RES INSTITUTE (US) | 2019-08-21 | — | — | EP | disclosed |
| US-9975918-B2 | Highly potent glucocorticoids | VAN ANDEL RESEARCH INSTITUTE (US) | 2018-05-22 | — | — | US | disclosed |
| US-9975918-B2 | Highly potent glucocorticoids | VAN ANDEL RESEARCH INSTITUTE (US) | 2018-05-22 | — | — | US | disclosed |
| WO-2018071736-A1 | STRUCTURES AND MECHANISM FOR THE DESIGN OF HIGHLY POTENT GLUCOCORTICOIDS | VAN ANDEL RESEARCH INSTITUTE (US) | 2018-04-19 | — | — | WO | disclosed |
| US-20160251393-A1 | Highly Potent Glucocorticoids | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-09-01 | — | — | US | disclosed |
| US-20160251393-A1 | Highly Potent Glucocorticoids | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-09-01 | — | — | US | disclosed |
| WO-2015048316-A1 | HIGHLY POTENT GLUCOCORTICOIDS | VAN ANDEL RESEARCH INSTITUTE (US) | 2015-04-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160251393-A1 | Highly Potent Glucocorticoids | NR3C1, NR3C2, MC2R | KDM4E 2582/4885MEN1 870/4885KMT2A 4497/4885 |
| US-20190263853-A1 | STRUCTURES AND MECHANISM FOR THE DESIGN OF HIGHLY POTENT GLUCOCORTICOIDS | NR3C1, NR3C2, MC2R | KDM4E 3645/4885MEN1 603/4885KMT2A 4796/4885 |
| US-10954265-B2 | Structures and mechanism for the design of highly potent glucocorticoids | NR3C1, NR3C2, MC2R | KDM4E 3645/4885MEN1 603/4885KMT2A 4796/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.