Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | HPGD | P15428 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | XBP1 | P17861 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.41 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1661557 | 0.79 | NPC1 (0.43) | GRM4ALDH1A1HPGDKDM4EPOLB | |
| SCHEMBL1662329 | 0.76 | KDM4E (0.50) | GRM4ALDH1A1HPGDKDM4EPOLB | |
| SCHEMBL1661700 | 0.75 | MAPT (0.41) | ALDH1A1HPGDKDM4ERAB9ANPSR1 | |
| SCHEMBL30807050 | 0.75 | MAPT (0.41) | ALDH1A1HPGDKDM4ERAB9ANPSR1 | |
| SCHEMBL1661512 | 0.74 | MAPT (0.41) | ALDH1A1HPGDKDM4ERAB9AMEN1 | |
| SCHEMBL16264455 | 0.72 | CYP2C9 (0.58) | ALDH1A1HPGDKDM4EPOLBRAB9A | |
| SCHEMBL6313268 | 0.72 | ADORA3 (0.49) | GRM4ALDH1A1HPGDKDM4EPOLB | |
| SCHEMBL6313274 | 0.72 | ADORA3 (0.49) | GRM4ALDH1A1HPGDKDM4EPOLB | |
| SCHEMBL19899702 | 0.72 | ALDH1A1 (0.39) | ALDH1A1HPGDKDM4ERAB9ALMNA | |
| SCHEMBL8160762 | 0.71 | PPARG (0.66) | ALDH1A1HPGDKDM4ERAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2306994-A1 | S1P1 RECEPTOR AGONISTS AND USE THEREOF | Amgen, Inc (US) | 2011-04-13 | — | — | EP | disclosed |
| WO-2009154775-A1 | S1P1 RECEPTOR AGONISTS AND USE THEREOF | AMGEN INC. (US) | 2009-12-23 | — | — | WO | disclosed |