Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | XBP1 | P17861 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.45 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.42 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6313268 | 1.00 | ADORA3 (0.49) | ADORA3ALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL25607336 | 0.79 | CYP1A2 (0.36) | ALDH1A1HPGDKDM4EMAPTMEN1 | |
| SCHEMBL16370488 | 0.75 | ALDH1A1 (0.59) | ADORA3ALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL9953407 | 0.72 | PPARG (0.66) | ADORA3ALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL8160762 | 0.72 | PPARG (0.66) | ADORA3ALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL10812842 | 0.72 | TARBP2 (0.59) | ADORA3ALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL10812846 | 0.72 | TARBP2 (0.59) | ADORA3ALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL1661513 | 0.72 | GRM4 (0.46) | ADORA3ALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL740361 | 0.71 | ADORA3 (0.49) | ADORA3ALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL740362 | 0.71 | ADORA3 (0.49) | ADORA3ALDH1A1HPGDKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6956049-B1 | Methods of modulating processes mediated by excitatory amino acid receptors | MERCK & CO., INC. (US) | 2005-10-18 | — | — | US | disclosed |
| EP-1214303-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF | Merck & Co., Inc. (US) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001016121-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF | MERCK & CO., INC. (US) | 2001-03-08 | — | — | WO | disclosed |