Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17969743 | 0.87 | MAPT (0.45) | SMN1; SMN2NPC1LMNAMAPTHTT | |
| SCHEMBL17918849 | 0.84 | MET (0.43) | SMN1; SMN2NPC1LMNAMAPTHTT | |
| SCHEMBL17918718 | 0.79 | CFTR (0.42) | SMN1; SMN2NPC1LMNAMAPTHTT | |
| SCHEMBL16615212 | 0.77 | MET (0.45) | NPC1MAPTALDH1A1HPGDKMT2A | |
| SCHEMBL16615213 | 0.76 | EPHX2 (0.43) | SMN1; SMN2NPC1LMNAMAPTHTT | |
| SCHEMBL17918788 | 0.76 | RAB9A (0.46) | SMN1; SMN2NPC1LMNAMAPTHTT | |
| SCHEMBL16615317 | 0.76 | MAPT (0.44) | SMN1; SMN2NPC1LMNAMAPTHTT | |
| SCHEMBL18106085 | 0.75 | MET (0.54) | KMT2AEPHX2MEN1 | |
| SCHEMBL16615101 | 0.74 | MET (0.46) | SMN1; SMN2NPC1MAPTALDH1A1HPGD | |
| SCHEMBL16615282 | 0.73 | NTRK1 (0.44) | SMN1; SMN2NPC1LMNAMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015047133-A1 | NOVEL CHEMICAL COMPOUNDS (VARIANTS) AND THE USE THEREOF TO TREAT ONCOLOGICAL DISEASES | ОБЩЕСТВО С ОГРАНИЧЕННОЙ ОТВЕТСТВЕННОСТЬЮ "ОТЕЧЕСТВЕННЫЕ ФАРМАЦЕВТИЧЕСКИЕ ТЕХНОЛОГИИ" | 2015-04-02 | — | — | WO | disclosed |