Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 5/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | PHGDH | O43175 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16615074 | 0.85 | MAPT (0.45) | EPHX2NPC1HPGDSMN1; SMN2LMNA | |
| SCHEMBL17918718 | 0.80 | CFTR (0.42) | EPHX2PDE4APDE7ANPC1HPGD | |
| SCHEMBL16615281 | 0.76 | SMN1; SMN2 (0.41) | EPHX2PDE4APDE7ANPC1HPGD | |
| SCHEMBL16615358 | 0.76 | CCNC (0.46) | MAPTFLT3 | |
| SCHEMBL17918849 | 0.76 | MET (0.43) | EPHX2PDE4APDE7ANPC1HPGD | |
| SCHEMBL16615299 | 0.75 | POLB (0.41) | EPHX2NPC1HPGDSMN1; SMN2LMNA | |
| SCHEMBL16615216 | 0.75 | ALK (0.49) | — | |
| SCHEMBL16615102 | 0.73 | MAPT (0.44) | PDE7ANPC1HPGDSMN1; SMN2LMNA | |
| SCHEMBL16615320 | 0.73 | MET (0.45) | NPC1HPGDSMN1; SMN2LMNAMAPT | |
| SCHEMBL16615168 | 0.71 | KMT2A (0.40) | SMN1; SMN2LMNAALDH1A1HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015047133-A1 | NOVEL CHEMICAL COMPOUNDS (VARIANTS) AND THE USE THEREOF TO TREAT ONCOLOGICAL DISEASES | ОБЩЕСТВО С ОГРАНИЧЕННОЙ ОТВЕТСТВЕННОСТЬЮ "ОТЕЧЕСТВЕННЫЕ ФАРМАЦЕВТИЧЕСКИЕ ТЕХНОЛОГИИ" | 2015-04-02 | — | — | WO | disclosed |