Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | HTT | P42858 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.65 |
| ▸ | PKM | P14618 | 1/20 | 0.65 |
| ▸ | CNR1 | P21554 | 1/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | CRHBP | P24387 | 2/20 | 0.61 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.61 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.57 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16615822 | 0.85 | ALDH1A1 (0.66) | SMN1; SMN2LMNAHTTMEN1MAPT | |
| SCHEMBL16615850 | 0.84 | SCN3A (0.65) | SMN1; SMN2LMNAHTTALDH1A1CRHBP | |
| SCHEMBL16615530 | 0.84 | ALDH1A1 (0.70) | SMN1; SMN2LMNAHTTMAPTCNR1 | |
| SCHEMBL16615489 | 0.83 | LMNA (0.70) | SMN1; SMN2LMNAHTTMEN1MAPT | |
| SCHEMBL9138268 | 0.82 | ALDH1A1 (0.68) | SMN1; SMN2LMNAHTTMEN1MAPT | |
| SCHEMBL16615514 | 0.81 | L3MBTL1 (0.62) | SMN1; SMN2LMNAHTTMEN1MAPT | |
| SCHEMBL16615791 | 0.80 | ALDH1A1 (0.65) | SMN1; SMN2LMNAHTTMEN1MAPT | |
| SCHEMBL7752354 | 0.80 | ALDH1A1 (0.82) | SMN1; SMN2LMNAHTTMEN1CYP3A4 | |
| SCHEMBL19074542 | 0.80 | ALDH1A1 (0.82) | SMN1; SMN2LMNAHTTMEN1CYP3A4 | |
| SCHEMBL8130545 | 0.79 | MEN1 (0.51) | SMN1; SMN2LMNAHTTMEN1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160213679-A1 | INHIBITORS OF POLYNUCLEOTIDE REPEAT-ASSOCIATED RNA FOCI AND USES THEREOF | Université de Montréal (CA) | 2016-07-28 | — | — | US | disclosed |
| US-20160213679-A1 | INHIBITORS OF POLYNUCLEOTIDE REPEAT-ASSOCIATED RNA FOCI AND USES THEREOF | Université de Montréal (CA) | 2016-07-28 | — | — | US | disclosed |
| WO-2015042685-A1 | INHIBITORS OF POLYNUCLEOTIDE REPEAT-ASSOCIATED RNA FOCI AND USES THEREOF | VALORISATION-RECHERCHE (CA) | 2015-04-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160213679-A1 | INHIBITORS OF POLYNUCLEOTIDE REPEAT-ASSOCIATED RNA FOCI AND USES THEREOF | FBL, HNRNPA1, HNRNPUL1 | SMN1; SMN2 81/4885LMNA 705/4885HTT 236/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.