SCHEMBL16616570

SCHEMBL16616570

CCN(C(=O)O)c1c(N)cc(NCc2ccc(F)cc2)cc1F

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNQ3 O43525 2/20 0.51
KCNQ2 O43526 2/20 0.51
KCNQ4 P56696 1/20 0.51
KCNQ5 Q9NR82 1/20 0.51
PPARA Q07869 8/20 0.44
P4HTM Q9NXG6 1/20 0.43
STING1 Q86WV6 1/20 0.40
KDM4E B2RXH2 3/20 0.40
GAA P10253 2/20 0.39
MAPT P10636 2/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
ALOX15 P16050 1/20 0.39
ALOX12 P18054 1/20 0.39
GFER P55789 1/20 0.39
F2 P00734 3/20 0.38
KLKB1 P03952 3/20 0.38
F10 P00742 2/20 0.38
LMNA P02545 1/20 0.38
HTT P42858 1/20 0.38
RAB9A P51151 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16616521 0.82 LMNA (0.44) KCNQ3KCNQ2KCNQ4KCNQ5PPARA
SCHEMBL16616466 0.77 KCNQ2 (0.46) KCNQ3KCNQ2KCNQ4KCNQ5PPARA
SCHEMBL15348110 0.74 KCNQ3 (0.56) KCNQ3KCNQ2KCNQ4KCNQ5PPARA
SCHEMBL16616598 0.74 KCNQ3 (0.45) KCNQ3KCNQ2KCNQ4KCNQ5PPARA
SCHEMBL16625700 0.73 KCNQ3 (0.53) KCNQ3KCNQ2KCNQ4KCNQ5PPARA
SCHEMBL15357202 0.71 KCNQ2 (0.74) KCNQ3KCNQ2KCNQ4KCNQ5PPARA
SCHEMBL15526607 0.71 KCNQ3 (0.52) KCNQ3KCNQ2KCNQ4KCNQ5PPARA
SCHEMBL16616629 0.71 KCNQ2 (0.57) KCNQ3KCNQ2KCNQ4KCNQ5PPARA
SCHEMBL1651597 0.70 KCNQ3 (0.74) KCNQ3KCNQ2KCNQ4KCNQ5PPARA
SCHEMBL4058596 0.70 KCNQ3 (0.56) KCNQ3KCNQ2P4HTMKDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9556114-B2 Fluorinated 2-amino-4-(benzylamino)phenylcarbamate derivatives SCIFLUOR LIFE SCIENCES, INC. (US) 2017-01-31 US disclosed
US-20150098902-A1 Fluorinated 2-Amino-4-(Benzylamino)Phenylcarbamate Derivatives SCIFLUOR LIFE SCIENCES, INC. 2015-04-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150098902-A1 Fluorinated 2-Amino-4-(Benzylamino)Phenylcarbamate Derivatives FAAH, CACNA1B, FAAH2 KCNQ3 48/4885KCNQ2 30/4885KCNQ4 55/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.