SCHEMBL16616673

SCHEMBL16616673

CCOC(=O)c1cc(C#N)c(O)nc1C

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 7/20 0.72
HSD17B10 Q99714 5/20 0.72
L3MBTL1 Q9Y468 5/20 0.69
GAA P10253 2/20 0.69
ALDH1A1 P00352 10/20 0.59
NPSR1 Q6W5P4 3/20 0.58
MAPT P10636 3/20 0.58
TSHR P16473 1/20 0.57
MAPK1 P28482 1/20 0.57
SMN1; SMN2 Q16637 1/20 0.57
MEN1 O00255 3/20 0.53
KMT2A Q03164 3/20 0.53
RXFP1 Q9HBX9 1/20 0.53
TDP1 Q9NUW8 3/20 0.53
HPGD P15428 2/20 0.50
RAB9A P51151 1/20 0.50
GPR55 Q9Y2T6 2/20 0.49
HTT P42858 1/20 0.49
POLB P06746 1/20 0.48
LMNA P02545 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29795690 0.95 KDM4E (0.66) KDM4EHSD17B10L3MBTL1GAAALDH1A1
SCHEMBL10254012 0.90 KDM4E (0.62) KDM4EHSD17B10L3MBTL1GAAALDH1A1
SCHEMBL17294334 0.88 KDM4E (0.64) KDM4EHSD17B10L3MBTL1GAAALDH1A1
SCHEMBL2229192 0.85 GAA (0.71) KDM4EHSD17B10L3MBTL1GAAALDH1A1
SCHEMBL3227432 0.84 KDM4E (0.71) KDM4EHSD17B10L3MBTL1GAAALDH1A1
SCHEMBL16624286 0.83 KDM4E (0.55) KDM4EHSD17B10L3MBTL1GAAALDH1A1
SCHEMBL23120427 0.82 KDM4E (0.64) KDM4EHSD17B10L3MBTL1GAAALDH1A1
SCHEMBL19601383 0.82 KDM4E (0.54) KDM4EHSD17B10L3MBTL1GAAALDH1A1
SCHEMBL16616256 0.82 KDM4E (0.54) KDM4EHSD17B10L3MBTL1GAAALDH1A1
SCHEMBL10378034 0.82 L3MBTL1 (1.00) KDM4EHSD17B10L3MBTL1GAAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114401963-B Pesticidally active cyclic amine compounds 先正达农作物保护股份公司 2025-03-14 CN disclosed
US-20240254086-A1 (HETERO)ARYLAMIDE COMPOUND AND PEST CONTROL AGENT NIPPON SODA CO., LTD. (JP) 2024-08-01 US disclosed
EP-4339187-A1 (HETERO)ARYLAMIDE COMPOUND AND PEST CONTROL AGENT Nippon Soda Co., Ltd. (JP) 2024-03-20 EP disclosed
CN-117279895-A (hetero) arylamide compound and pest control agent 日本曹达株式会社 2023-12-22 CN disclosed
US-20220389000-A1 PESTICIDALLY ACTIVE CYCLIC AMINE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2022-12-08 US disclosed
WO-2022239798-A1 (HETERO)ARYLAMIDE COMPOUND AND PEST CONTROL AGENT 日本曹達株式会社 2022-11-17 WO disclosed
WO-2022239798-A1 (HETERO)ARYLAMIDE COMPOUND AND PEST CONTROL AGENT 日本曹達株式会社 2022-11-17 WO disclosed
EP-4031545-A1 PESTICIDALLY ACTIVE CYCLIC AMINE COMPOUNDS Syngenta Crop Protection AG (CH) 2022-07-27 EP disclosed
CN-114401963-A Pesticidally active cyclic amine compounds 先正达农作物保护股份公司 2022-04-26 CN disclosed
WO-2021053161-A1 PESTICIDALLY ACTIVE CYCLIC AMINE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2021-03-25 WO disclosed
US-20160237087-A1 HETEROCYCLIC COMPOUNDS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2016-08-18 US disclosed
US-20160237087-A1 HETEROCYCLIC COMPOUNDS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2016-08-18 US disclosed
EP-3055309-A1 ANTAGONISTS OF SOMATOSTATIN RECEPTOR SUBTYPE 5 (SSTR5) Takeda Pharmaceutical Company Limited (JP) 2016-08-17 EP disclosed
US-9353108-B2 Tetrahydronaphthyridine somatostatin receptor 5 antagonists TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2016-05-31 US disclosed
US-9353108-B2 Tetrahydronaphthyridine somatostatin receptor 5 antagonists TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2016-05-31 US disclosed
US-9353108-B2 Tetrahydronaphthyridine somatostatin receptor 5 antagonists TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2016-05-31 US disclosed
WO-2015052910-A1 ANTAGONISTS OF SOMATOSTATIN RECEPTOR SUBTYPE 5 (SSTR5) TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2015-04-16 WO disclosed
US-20150099777-A1 HETEROCYCLIC COMPOUND TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2015-04-09 US disclosed
US-20150099777-A1 HETEROCYCLIC COMPOUND TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2015-04-09 US disclosed
US-20150099777-A1 HETEROCYCLIC COMPOUND TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2015-04-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150099777-A1 HETEROCYCLIC COMPOUND SSTR5, SSTR4, SSTR2 KDM4E 3637/4885HSD17B10 2159/4885L3MBTL1 4878/4885
US-20160237087-A1 HETEROCYCLIC COMPOUNDS SSTR5, SSTR4, SSTR2 KDM4E 3670/4885HSD17B10 2236/4885L3MBTL1 4879/4885
US-20220389000-A1 PESTICIDALLY ACTIVE CYCLIC AMINE COMPOUNDS DDT, ACHE, PNMT KDM4E 2360/4885HSD17B10 3333/4885L3MBTL1 2034/4885
US-20240254086-A1 (HETERO)ARYLAMIDE COMPOUND AND PEST CONTROL AGENT H1-2, CTRL, BOLA2; BOLA2B KDM4E 2077/4885HSD17B10 1582/4885L3MBTL1 13/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.