Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 3/20 | 0.45 |
| ▸ | RIN1 | Q13671 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 5/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PHGDH | O43175 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16617949 | 0.88 | HPGD (0.44) | ABL1RIN1HPGDHRH3GAA | |
| SCHEMBL16617950 | 0.88 | HPGD (0.44) | ABL1RIN1HPGDHRH3GAA | |
| SCHEMBL16617338 | 0.80 | HPGD (0.41) | HPGDPOLBPHGDHALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL16617816 | 0.79 | HPGD (0.40) | HPGDPOLBPHGDHALDH1A1SMN1; SMN2 | |
| SCHEMBL16617396 | 0.75 | POLB (0.38) | HPGDPOLBPHGDHALDH1A1SMN1; SMN2 | |
| SCHEMBL16617711 | 0.73 | PTGER4 (0.38) | HRH3GAAPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL16617713 | 0.73 | PTGER4 (0.38) | HRH3GAAPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL16617175 | 0.70 | PTGER4 (0.38) | POLBALDH1A1SMN1; SMN2KMT2ANPC1 | |
| SCHEMBL16617178 | 0.70 | PTGER4 (0.38) | POLBALDH1A1SMN1; SMN2KMT2ANPC1 | |
| SCHEMBL16617856 | 0.69 | ALDH1A1 (0.41) | HPGDHRH3POLBPHGDHALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3055314-B1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-09-12 | — | — | EP | disclosed |
| US-9458181-B2 | Cathepsin cysteine protease inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-10-04 | — | — | US | disclosed |
| US-20150099719-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK SHARP & DOHME LLC | 2015-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150099719-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | CTSB, CTSS, CTSZ | ABL1 2349/4885RIN1 1757/4885HPGD 3020/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.