Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 18/20 | 0.52 |
| ▸ | CTSB | P07858 | 2/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16617318 | 1.00 | CTSK (0.52) | CTSKCTSBCTSSJAK2JAK1 | |
| SCHEMBL16617793 | 0.94 | CTSK (0.51) | CTSKCTSB | |
| SCHEMBL16617319 | 0.94 | CTSK (0.51) | CTSKCTSB | |
| SCHEMBL16617548 | 0.89 | CTSK (0.58) | CTSKCTSBCTSS | |
| SCHEMBL16638062 | 0.83 | CTSK (0.65) | CTSKCTSBCTSS | |
| SCHEMBL16617545 | 0.83 | CTSK (0.65) | CTSKCTSBCTSS | |
| SCHEMBL16617317 | 0.81 | CTSK (0.49) | CTSKCTSBCTSS | |
| SCHEMBL16617999 | 0.79 | CTSK (0.56) | CTSKCTSBCTSS | |
| SCHEMBL16617459 | 0.78 | CTSK (0.57) | CTSKCTSBCTSS | |
| SCHEMBL16617126 | 0.78 | CTSK (0.73) | CTSKCTSBCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150099719-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK SHARP & DOHME LLC | 2015-04-09 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150099719-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | CTSB, CTSS, CTSZ | CTSK 4/4885CTSB 1/4885CTSS 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.