Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 20/20 | 0.51 |
| ▸ | CTSB | P07858 | 13/20 | 0.51 |
| ▸ | CTSS | P25774 | 10/20 | 0.49 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16637533 | 1.00 | CTSK (0.51) | CTSKCTSBCTSSCTSLCYP3A4 | |
| SCHEMBL16626986 | 0.87 | CTSK (0.42) | CTSKCTSBCTSSCTSLCYP3A4 | |
| SCHEMBL16638069 | 0.85 | CTSK (0.65) | CTSKCTSBCTSSKCNH2 | |
| SCHEMBL16617466 | 0.85 | CTSK (0.65) | CTSKCTSBCTSSKCNH2 | |
| SCHEMBL16617465 | 0.85 | CTSK (0.57) | CTSKCTSBCTSSKCNH2 | |
| SCHEMBL16626983 | 0.80 | CTSK (0.57) | CTSKCTSBCTSSCTSLCYP3A4 | |
| SCHEMBL16617631 | 0.80 | CTSK (0.56) | CTSKCTSBCTSSCTSLCYP3A4 | |
| SCHEMBL16637996 | 0.80 | CTSK (0.56) | CTSKCTSBCTSSCTSLCYP3A4 | |
| SCHEMBL16636257 | 0.78 | CTSK (0.59) | CTSKCTSBCTSSCTSLCYP3A4 | |
| SCHEMBL16636397 | 0.77 | CTSK (0.57) | CTSKCTSBCTSSCTSLCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3055314-B1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-09-12 | — | — | EP | claimed |
| US-9458181-B2 | Cathepsin cysteine protease inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-10-04 | — | — | US | claimed |
| US-20150099719-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK SHARP & DOHME LLC | 2015-04-09 | — | — | US | claimed |
| US-9458181-B2 | Cathepsin cysteine protease inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-10-04 | — | — | US | disclosed |
| WO-2015054089-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-04-16 | — | — | WO | disclosed |
| US-20150099719-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK SHARP & DOHME LLC | 2015-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150099719-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | CTSB, CTSS, CTSZ | CTSK 4/4885CTSB 1/4885CTSS 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.