Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | HTT | P42858 | 7/20 | 0.50 |
| ▸ | LMNA | P02545 | 6/20 | 0.50 |
| ▸ | ALPL | P05186 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | MYC | P01106 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.45 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.44 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30744822 | 0.81 | CTSD (0.62) | SMN1; SMN2ALDH1A1LMNAGAANPC1 | |
| SCHEMBL1655461 | 0.81 | SMN1; SMN2 (0.56) | SMN1; SMN2ALDH1A1HTTLMNAALPL | |
| SCHEMBL2169790 | 0.81 | CTSD (0.62) | SMN1; SMN2ALDH1A1LMNAGAANPC1 | |
| SCHEMBL29646356 | 0.78 | CTSD (0.62) | SMN1; SMN2ALDH1A1HTTLMNAALPL | |
| SCHEMBL22987538 | 0.78 | CTSD (0.62) | SMN1; SMN2ALDH1A1HTTLMNAALPL | |
| SCHEMBL7983685 | 0.77 | HCRTR1 (0.65) | ALDH1A1GAARAB9AMAPTKDM4E | |
| SCHEMBL17206370 | 0.76 | SMN1; SMN2 (0.51) | SMN1; SMN2ALDH1A1HTTLMNAALPL | |
| SCHEMBL1856862 | 0.76 | SLC6A3 (0.56) | SMN1; SMN2ALDH1A1HTTLMNAALPL | |
| SCHEMBL16239783 | 0.75 | SCN9A (0.53) | SCN9A | |
| SCHEMBL1286684 | 0.75 | IRAK4 (0.53) | SMN1; SMN2ALDH1A1HTTLMNAALPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015051043-A1 | BIARYL ACYL-SULFONAMIDE COMPOUNDS AS SODIUM CHANNEL INHIBITORS | AMGEN INC. (US) | 2015-04-09 | — | — | WO | disclosed |